Multivariate Cox proportional hazards model for OS among RAEB patients (N = 336)
| Characteristics . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| HMA-type decitabine (ref = azacitidine) | 0.96 (0.70-1.31) | .78 |
| ESA use pre-HMA (ref = No) | 1.05 (0.80-1.37) | .73 |
| Year of MDS diagnosis (ref = 2004-2005) | .96 | |
| 2006-2007 | 0.95 (0.66-1.36) | |
| 2008 | 0.96 (0.65-1.40) | |
| Time to first HMA, mo | 0.98 (0.96-1.00) | .02 |
| Age group, y (ref = 66-69) | .14 | |
| 70-74 | 1.33 (0.92-1.92) | |
| 75-79 | 1.36 (0.94-1.97) | |
| 80+ | 1.58 (1.08-2.30) | |
| Sex (ref = male) | 0.95 (0.75-1.21) | .69 |
| Race other than white (ref = white) | 0.76 (0.53-1.11) | .16 |
| Hispanic (ref = no) | 1.61 (0.90-2.86) | .11 |
| Marital status (ref = married) | .06 | |
| Single/Div/Sep/Wid/Unmarried | 1.03 (0.78-1.37) | |
| Unknown | 0.60 (0.39-0.94) | |
| Elixhauser Comorbidity Index pre-HMA (ref = 0) | .44 | |
| 1-2 | 0.81 (0.59-1.12) | |
| >3 | 0.89 (0.63-1.25) | |
| Disability (ref = not disabled) | .87 | |
| Disabled | 1.05 (0.62-1.78) | |
| RBC transfusion group (ref = 0) | <.001 | |
| 1-2 | 1.76 (1.29-2.41) | |
| ≥3 | 1.95 (1.43-2.65) | |
| Platelet transfusion group (ref = 0) | .01 | |
| 1-2 | 1.56 (0.95-2.57) | |
| ≥3 | 1.89 (1.21-2.96) | |
| Adults 25+ y in zip code with ≤ HS education, % (ref ≤ 33%) | .46 | |
| 33-66 | 1.07 (0.79-1.44) | |
| ≥66 | 0.83 (0.50-1.37) | |
| Income (ref = <$33 000) | .89 | |
| $33 000-40 000 | 0.92 (0.57-1.48) | |
| $40 000-50 000 | 0.86 (0.56-1.30) | |
| ≥$50 000 | 0.94 (0.60-1.46) | |
| Metro (ref = metro area) | .30 | |
| Nonmetro | 1.22 (0.84-1.78) |
| Characteristics . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| HMA-type decitabine (ref = azacitidine) | 0.96 (0.70-1.31) | .78 |
| ESA use pre-HMA (ref = No) | 1.05 (0.80-1.37) | .73 |
| Year of MDS diagnosis (ref = 2004-2005) | .96 | |
| 2006-2007 | 0.95 (0.66-1.36) | |
| 2008 | 0.96 (0.65-1.40) | |
| Time to first HMA, mo | 0.98 (0.96-1.00) | .02 |
| Age group, y (ref = 66-69) | .14 | |
| 70-74 | 1.33 (0.92-1.92) | |
| 75-79 | 1.36 (0.94-1.97) | |
| 80+ | 1.58 (1.08-2.30) | |
| Sex (ref = male) | 0.95 (0.75-1.21) | .69 |
| Race other than white (ref = white) | 0.76 (0.53-1.11) | .16 |
| Hispanic (ref = no) | 1.61 (0.90-2.86) | .11 |
| Marital status (ref = married) | .06 | |
| Single/Div/Sep/Wid/Unmarried | 1.03 (0.78-1.37) | |
| Unknown | 0.60 (0.39-0.94) | |
| Elixhauser Comorbidity Index pre-HMA (ref = 0) | .44 | |
| 1-2 | 0.81 (0.59-1.12) | |
| >3 | 0.89 (0.63-1.25) | |
| Disability (ref = not disabled) | .87 | |
| Disabled | 1.05 (0.62-1.78) | |
| RBC transfusion group (ref = 0) | <.001 | |
| 1-2 | 1.76 (1.29-2.41) | |
| ≥3 | 1.95 (1.43-2.65) | |
| Platelet transfusion group (ref = 0) | .01 | |
| 1-2 | 1.56 (0.95-2.57) | |
| ≥3 | 1.89 (1.21-2.96) | |
| Adults 25+ y in zip code with ≤ HS education, % (ref ≤ 33%) | .46 | |
| 33-66 | 1.07 (0.79-1.44) | |
| ≥66 | 0.83 (0.50-1.37) | |
| Income (ref = <$33 000) | .89 | |
| $33 000-40 000 | 0.92 (0.57-1.48) | |
| $40 000-50 000 | 0.86 (0.56-1.30) | |
| ≥$50 000 | 0.94 (0.60-1.46) | |
| Metro (ref = metro area) | .30 | |
| Nonmetro | 1.22 (0.84-1.78) |
Div, divorced; ESA, erythropoiesis-stimulating agent; HS, high school; ref, reference value; Sep, separated; Wid, widowed.