Table 2. Predictions based on the... | American Society of Hematology

Table 2.

Predictions based on the combined CLL8, CLL10, and CLL11 meta-regression model

Ratio of MRD⁻ rates, relative risk*	Log of relative risk	Predicted PFS HR	Individual prediction,† 95% CL	Mean prediction,‡ 95% CL	Prediction in a phase 3 study,§ 95% CL
2	0.69	0.59	0.32, 1.09	0.50, 0.69	0.43, 0.81
1.75	0.56	0.60	0.33, 1.12	0.51, 0.71	0.44, 0.83
1.5	0.41	0.62	0.33, 1.16	0.52, 0.74	0.45, 0.86
1.37	0.31	0.63	0.34, 1.18	0.52, 0.76	0.45, 0.88
1.25	0.22	0.64	0.34, 1.20	0.53, 0.78	0.46, 0.90
1.2	0.18	0.65	0.35, 1.21	0.53, 0.79	0.46, 0.91
1	0	0.67	0.36, 1.26	0.54, 0.84	0.47, 0.95

Ratio of MRD⁻ rates, relative risk*	Log of relative risk	Predicted PFS HR	Individual prediction,† 95% CL	Mean prediction,‡ 95% CL	Prediction in a phase 3 study,§ 95% CL
2	0.69	0.59	0.32, 1.09	0.50, 0.69	0.43, 0.81
1.75	0.56	0.60	0.33, 1.12	0.51, 0.71	0.44, 0.83
1.5	0.41	0.62	0.33, 1.16	0.52, 0.74	0.45, 0.86
1.37	0.31	0.63	0.34, 1.18	0.52, 0.76	0.45, 0.88
1.25	0.22	0.64	0.34, 1.20	0.53, 0.78	0.46, 0.90
1.2	0.18	0.65	0.35, 1.21	0.53, 0.79	0.46, 0.91
1	0	0.67	0.36, 1.26	0.54, 0.84	0.47, 0.95

MRD⁻ rate in experimental arm/MRD⁻ rate in control arm.

Prediction for observation of PFS HR in a single trial.

Prediction for PFS HR underlying mean value.

Prediction for observation of PFS HR in a new study with 170 PFS events (reflects a target HR of 0.65).