EBV-related cHL according to the immunocompetence status of the host
| Host/Hodgkin lymphoma . | EBV infection . |
|---|---|
| Without known immunosuppression | |
| cHL, NS | Variably present |
| cHL, MC | Usually present |
| Rare subtypes | Variably present |
| With acquired immunodeficiency | |
| HIV-associated cHL | Present |
| Posttransplant, cHL type PTLD | Present |
| Iatrogenic, methotrexate | Variably present |
| Host/Hodgkin lymphoma . | EBV infection . |
|---|---|
| Without known immunosuppression | |
| cHL, NS | Variably present |
| cHL, MC | Usually present |
| Rare subtypes | Variably present |
| With acquired immunodeficiency | |
| HIV-associated cHL | Present |
| Posttransplant, cHL type PTLD | Present |
| Iatrogenic, methotrexate | Variably present |
EBV association varies according to the immunocompetence status of the host and cHL subtype.1,16,17 EBV is found in HRS cells in nearly all cases of cHL occurring in patients infected with HIV.
PTLD, posttransplant lymphoproliferative disorder.