Characteristics of patients according to their N/F, PTEN, and RAS status
| . | All patients . | N/F . | PTEN . | K/N-RAS . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (N = 220) . | Mut, 134 (61%) . | WT, 86 (39%) . | P* . | Altered, 30 (14%) . | Not altered 190 (86%) . | P* . | Mut 18 (8%) . | WT 202 (92%) . | P* . | |
| Genotype subsets analyzed | 134 | 88 | 46 | — | 22 | 112 | — | 14 | 120 | — |
| CALM-AF10 | 5 (4) | 2 (2) | 3 (6) | NS | 2 (9) | 3 (3) | NS | 0 | 5 (4) | NS |
| SIL-TAL1 | 18 (13) | 9 (10) | 9 (20) | NS | 8 (36) | 10 (9) | .002 | 1 (7) | 17 (14) | NS |
| TLX1 | 9 (7) | 7 (8) | 2 (4) | NS | 1 (4) | 8 (7) | NS | 1 (7) | 8 (7) | NS |
| TLX3 | 35 (26) | 24 (27) | 11 (24) | NS | 2 (10) | 33 (29) | NS | 7 (50) | 28 (23) | .049 |
| None of above | 67 (50) | 46 (52) | 21 (46) | NS | 9 (41) | 58 (52) | NS | 5 (36) | 62 (52) | NS |
| N/Fmutated | 134 (61) | 134 (100) | 0 | — | 16 (53) | 118 (62) | NS | 7 (39) | 127 (63) | NS |
| PTENaltered | 30 (14) | 16 (12) | 14 (16) | NS | 30 (100) | 0 | — | 2 (11) | 28 (14) | NS |
| K/N-RASmutated | 18 (8) | 7 (5) | 11 (13) | NS | 2 (7) | 16 (8) | NS | 18 (100) | 0 | — |
| Clinical features | ||||||||||
| Age, median (range), y | 9.5 (1.1-19.5) | 9.8 | 8.9 | NS | 8.7 | 9.5 | NS | 9.3 | 9.5 | NS |
| Median WBC, ×109/L | 100 | 101.5 | 93.9 | NS | 162.5 | 79.8 | .027 | 82 | 97 | NS |
| WBC count ≥200 × 109/L | 55 (25) | 27 (20) | 28 (32) | NS | 12 (40) | 43 (23) | NS | 4 (22) | 51 (25) | NS |
| CNS involvement | 18 (8) | 11 (8) | 7 (8) | NS | 2 (7) | 16 (8) | NS | 0 | 18 (9) | NS |
| Day 8 GPR | 125 (60) | 84 (65) | 41 (50) | .03 | 11 (37) | 114 (60) | .014 | 10 (59) | 115 (60) | NS |
| Day 21 CHs | 186 (87) | 117 (90) | 69 (83) | NS | 28 (93) | 158 (83) | NS | 14 (82) | 172 (87) | NS |
| CR | 213 (97) | 132 (98) | 81 (94) | NS | 30 (100) | 183 (96) | NS | 15 (83) | 191 (95) | NS |
| MRD <10−4 | 114/192 (59) | 82/118 (69) | 32/74 (43) | .0006 | 15/26 (58) | 99/166 (60) | NS | 6/15 (40) | 108/177 (61) | NS |
| . | All patients . | N/F . | PTEN . | K/N-RAS . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| (N = 220) . | Mut, 134 (61%) . | WT, 86 (39%) . | P* . | Altered, 30 (14%) . | Not altered 190 (86%) . | P* . | Mut 18 (8%) . | WT 202 (92%) . | P* . | |
| Genotype subsets analyzed | 134 | 88 | 46 | — | 22 | 112 | — | 14 | 120 | — |
| CALM-AF10 | 5 (4) | 2 (2) | 3 (6) | NS | 2 (9) | 3 (3) | NS | 0 | 5 (4) | NS |
| SIL-TAL1 | 18 (13) | 9 (10) | 9 (20) | NS | 8 (36) | 10 (9) | .002 | 1 (7) | 17 (14) | NS |
| TLX1 | 9 (7) | 7 (8) | 2 (4) | NS | 1 (4) | 8 (7) | NS | 1 (7) | 8 (7) | NS |
| TLX3 | 35 (26) | 24 (27) | 11 (24) | NS | 2 (10) | 33 (29) | NS | 7 (50) | 28 (23) | .049 |
| None of above | 67 (50) | 46 (52) | 21 (46) | NS | 9 (41) | 58 (52) | NS | 5 (36) | 62 (52) | NS |
| N/Fmutated | 134 (61) | 134 (100) | 0 | — | 16 (53) | 118 (62) | NS | 7 (39) | 127 (63) | NS |
| PTENaltered | 30 (14) | 16 (12) | 14 (16) | NS | 30 (100) | 0 | — | 2 (11) | 28 (14) | NS |
| K/N-RASmutated | 18 (8) | 7 (5) | 11 (13) | NS | 2 (7) | 16 (8) | NS | 18 (100) | 0 | — |
| Clinical features | ||||||||||
| Age, median (range), y | 9.5 (1.1-19.5) | 9.8 | 8.9 | NS | 8.7 | 9.5 | NS | 9.3 | 9.5 | NS |
| Median WBC, ×109/L | 100 | 101.5 | 93.9 | NS | 162.5 | 79.8 | .027 | 82 | 97 | NS |
| WBC count ≥200 × 109/L | 55 (25) | 27 (20) | 28 (32) | NS | 12 (40) | 43 (23) | NS | 4 (22) | 51 (25) | NS |
| CNS involvement | 18 (8) | 11 (8) | 7 (8) | NS | 2 (7) | 16 (8) | NS | 0 | 18 (9) | NS |
| Day 8 GPR | 125 (60) | 84 (65) | 41 (50) | .03 | 11 (37) | 114 (60) | .014 | 10 (59) | 115 (60) | NS |
| Day 21 CHs | 186 (87) | 117 (90) | 69 (83) | NS | 28 (93) | 158 (83) | NS | 14 (82) | 172 (87) | NS |
| CR | 213 (97) | 132 (98) | 81 (94) | NS | 30 (100) | 183 (96) | NS | 15 (83) | 191 (95) | NS |
| MRD <10−4 | 114/192 (59) | 82/118 (69) | 32/74 (43) | .0006 | 15/26 (58) | 99/166 (60) | NS | 6/15 (40) | 108/177 (61) | NS |
Values represent n (%) of patients unless otherwise indicated.
CH, chemosensitivity (defined by blasts ≤5% in bone marrow); CNS, central nervous system; GPR, good PR; Mut, mutated; NA, not applicable; NS, not significant; WT, wild-type.
Student t test or Fisher’s exact test where appropriate.