Clinical and laboratory findings that might herald malignant progression
Clinical signs/symptoms (unexplained) . |
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1. Anemia |
2. Cardiomyopathy (restrictive) |
3. Diarrhea |
4. Fracture |
5. Hepatomegaly |
6. Hypercalcemia |
7. Hyperviscosity (in the setting of IgM M-protein) |
8. Intestinal pseudo-obstruction |
9. Lytic lesion |
10. Macroglossia |
11. Nephrotic syndrome |
12. Neuropathy (autonomic, sensory, or motor) |
13. Purpura |
14. Renal insufficiency |
Clinical signs/symptoms (unexplained) . |
---|
1. Anemia |
2. Cardiomyopathy (restrictive) |
3. Diarrhea |
4. Fracture |
5. Hepatomegaly |
6. Hypercalcemia |
7. Hyperviscosity (in the setting of IgM M-protein) |
8. Intestinal pseudo-obstruction |
9. Lytic lesion |
10. Macroglossia |
11. Nephrotic syndrome |
12. Neuropathy (autonomic, sensory, or motor) |
13. Purpura |
14. Renal insufficiency |
Monoclonal protein studies . |
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1. Serum M-protein: IgG or IgA ≥3.0 g/dL |
2. Urine M-protein ≥ 500 mg in 24 h |
3. Serum κ or λ free light chain ≥100 mg/dL and involved/uninvolved FLC >100 |
4. 50% increase in serum monoclonal protein (absolute increase of ≥0.5 g/dL) |
Monoclonal protein studies . |
---|
1. Serum M-protein: IgG or IgA ≥3.0 g/dL |
2. Urine M-protein ≥ 500 mg in 24 h |
3. Serum κ or λ free light chain ≥100 mg/dL and involved/uninvolved FLC >100 |
4. 50% increase in serum monoclonal protein (absolute increase of ≥0.5 g/dL) |