MGUS follow-up recommendations from clinical practice guidelines
| MGUS risk/recommended tests . | UK Myeloma Forum/Nordic Study Group (2009)14 . | International Expert Consensus (2010)16 . | International Myeloma Working Group (2010)15 . | European Myeloma Network (2014)17 . |
|---|---|---|---|---|
| Low-risk MGUS (IgG, <1.5 gm/dL, and normal FLC ratio) | First year, every 3-4 mo; then every 6-12 mo if stable | First 2 y, every 4-6 mo; then every 6-24 mo | At 6 mo; then every 2-3 y if stable | At 6 mo; then every 1-2 y if stable or no follow-up |
| All other MGUS | At least every 3-4 mo | First 2 y, every 4-6 mo; then every 6-24 mo | At 6 mo; then every year if stable | At 6 mo; then every year thereafter |
| Life expectancy <5 y | Can consider discontinuing follow-up | Not mentioned | Not mentioned | No follow-up |
| Recommended tests | Quantification of M-protein | Quantification of M-protein | Quantification of M-protein | Quantification of M-protein |
| Serum urea nitrogen | CBC | CBC | ||
| CBC | Calcium | |||
| Calcium | Creatinine | |||
| Creatinine | ||||
| Electrolytes | ||||
| Immunoglobulin levels |
| MGUS risk/recommended tests . | UK Myeloma Forum/Nordic Study Group (2009)14 . | International Expert Consensus (2010)16 . | International Myeloma Working Group (2010)15 . | European Myeloma Network (2014)17 . |
|---|---|---|---|---|
| Low-risk MGUS (IgG, <1.5 gm/dL, and normal FLC ratio) | First year, every 3-4 mo; then every 6-12 mo if stable | First 2 y, every 4-6 mo; then every 6-24 mo | At 6 mo; then every 2-3 y if stable | At 6 mo; then every 1-2 y if stable or no follow-up |
| All other MGUS | At least every 3-4 mo | First 2 y, every 4-6 mo; then every 6-24 mo | At 6 mo; then every year if stable | At 6 mo; then every year thereafter |
| Life expectancy <5 y | Can consider discontinuing follow-up | Not mentioned | Not mentioned | No follow-up |
| Recommended tests | Quantification of M-protein | Quantification of M-protein | Quantification of M-protein | Quantification of M-protein |
| Serum urea nitrogen | CBC | CBC | ||
| CBC | Calcium | |||
| Calcium | Creatinine | |||
| Creatinine | ||||
| Electrolytes | ||||
| Immunoglobulin levels |
CBC, complete blood count.