Table 3.

MGUS follow-up recommendations from clinical practice guidelines

MGUS risk/recommended testsUK Myeloma Forum/Nordic Study Group (2009)14 International Expert Consensus (2010)16 International Myeloma Working Group (2010)15 European Myeloma Network (2014)17 
Low-risk MGUS (IgG, <1.5 gm/dL, and normal FLC ratio) First year, every 3-4 mo; then every 6-12 mo if stable First 2 y, every 4-6 mo; then every 6-24 mo At 6 mo; then every 2-3 y if stable At 6 mo; then every 1-2 y if stable or no follow-up 
All other MGUS At least every 3-4 mo First 2 y, every 4-6 mo; then every 6-24 mo At 6 mo; then every year if stable At 6 mo; then every year thereafter 
Life expectancy <5 y Can consider discontinuing follow-up Not mentioned Not mentioned No follow-up 
Recommended tests Quantification of M-protein Quantification of M-protein Quantification of M-protein Quantification of M-protein 
Serum urea nitrogen CBC CBC 
CBC  Calcium 
Calcium  Creatinine 
Creatinine   
Electrolytes   
Immunoglobulin levels   
MGUS risk/recommended testsUK Myeloma Forum/Nordic Study Group (2009)14 International Expert Consensus (2010)16 International Myeloma Working Group (2010)15 European Myeloma Network (2014)17 
Low-risk MGUS (IgG, <1.5 gm/dL, and normal FLC ratio) First year, every 3-4 mo; then every 6-12 mo if stable First 2 y, every 4-6 mo; then every 6-24 mo At 6 mo; then every 2-3 y if stable At 6 mo; then every 1-2 y if stable or no follow-up 
All other MGUS At least every 3-4 mo First 2 y, every 4-6 mo; then every 6-24 mo At 6 mo; then every year if stable At 6 mo; then every year thereafter 
Life expectancy <5 y Can consider discontinuing follow-up Not mentioned Not mentioned No follow-up 
Recommended tests Quantification of M-protein Quantification of M-protein Quantification of M-protein Quantification of M-protein 
Serum urea nitrogen CBC CBC 
CBC  Calcium 
Calcium  Creatinine 
Creatinine   
Electrolytes   
Immunoglobulin levels   

CBC, complete blood count.

or Create an Account

Close Modal
Close Modal