Table 3. Schedules and doses used in... | American Society of Hematology

Table 3.

Schedules and doses used in regimens for older patients

Regimen	Drug	Dose, mg/m²	Administration		Length of cycle, d
Regimen	Drug	Dose, mg/m²	Route	Days of	Length of cycle, d
ChlVPP/EVA	Chlorambucil*	6	PO	1-7	28
	Vinblastine†	6	IV	8
	Procarbazine	90	PO	1-7
	Prednisone	50	PO	1-7
	Etoposide	75	PO	1-5
	Vincristine‡	1.4	IV	1
	Doxorubicin	50	IV	8
ChlVPP	Chlorambucil*	6	PO	1-14	28
	Vinblastine†	6	IV	1 and 8
	Procarbazine	100	PO	1-14
	Prednisone	40	PO	1-14
VEPEMB	Vinblastine†	6	IV	1	28
	Cyclophosphamide	500	IV	1
	Procarbazine	100	PO	1-5
	Prednisone	30	PO	1-5
	Etoposide	60	PO	15-19
	Mitoxantrone	6	IV	15
	Bleomycin	10	IV	15
PVAG	Prednisone	40	PO	1-5	22
	Vinblastine†	6	IV	1
	Doxorubicin	50	IV	1
	Gemcitabine	1000	IV	1

Regimen	Drug	Dose, mg/m²	Administration		Length of cycle, d
Regimen	Drug	Dose, mg/m²	Route	Days of	Length of cycle, d
ChlVPP/EVA	Chlorambucil*	6	PO	1-7	28
	Vinblastine†	6	IV	8
	Procarbazine	90	PO	1-7
	Prednisone	50	PO	1-7
	Etoposide	75	PO	1-5
	Vincristine‡	1.4	IV	1
	Doxorubicin	50	IV	8
ChlVPP	Chlorambucil*	6	PO	1-14	28
	Vinblastine†	6	IV	1 and 8
	Procarbazine	100	PO	1-14
	Prednisone	40	PO	1-14
VEPEMB	Vinblastine†	6	IV	1	28
	Cyclophosphamide	500	IV	1
	Procarbazine	100	PO	1-5
	Prednisone	30	PO	1-5
	Etoposide	60	PO	15-19
	Mitoxantrone	6	IV	15
	Bleomycin	10	IV	15
PVAG	Prednisone	40	PO	1-5	22
	Vinblastine†	6	IV	1
	Doxorubicin	50	IV	1
	Gemcitabine	1000	IV	1

ChlVPP, chlorambucil, vinblastine, procarbazine, and prednisolone; EVA, etoposide, vincristine, doxorubicin (Adriamycin); PVAG, prednisone, vinblastine, doxorubicin, gemcitabine; VEPEMB, vinblastine, cyclophosphamide, procarbazine, prednisolone, etoposide, mitoxantrone, and bleomycin. Other abbreviations are explained in Table 2.

Chlorambucil is capped at 10 mg per administration.

†

Vinblastine is capped at 10 mg per administration.

‡

Vincristine is capped at 2 mg per administration.

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