Table 2. Selected front-line trials in... | American Society of Hematology

Table 2.

Selected front-line trials in younger patients

Regimen	Drug	Dose, mg/m²	Administration		Length of cycle, d
Regimen	Drug	Dose, mg/m²	Route	Days of	Length of cycle, d
ABVD	Doxorubicin	25	IV	1 and 15	28
	Bleomycin	10	IV	1 and 15
	Vinblastine*	6	IV	1 and 15
	Dacarbazine	375	IV	1 and 15
stdBEACOPP/BEACOPP-14	Bleomycin	10	IV	8	14-21
	Etoposide	100	IV	1-3
	Doxorubicin	25	IV	1
	Cyclophosphamide	650	IV	1
	Vincristine†	1.4	IV	8
	Procarbazine	100	PO	1-7
	Prednisone‡	40-80	PO	1-14 or 1-7
	GCSF			9-13
escBEACOPP	Bleomycin	10	IV	8	21
	Etoposide	200	IV	1-3
	Doxorubicin	35	IV	1
	Cyclophosphamide	1200	IV	1
	Vincristine†	1.4	IV	8
	Procarbazine	100	PO	1-7
	Prednisone	40	PO	1-14
	GCSF			Day 9 until recovery

Regimen	Drug	Dose, mg/m²	Administration		Length of cycle, d
Regimen	Drug	Dose, mg/m²	Route	Days of	Length of cycle, d
ABVD	Doxorubicin	25	IV	1 and 15	28
	Bleomycin	10	IV	1 and 15
	Vinblastine*	6	IV	1 and 15
	Dacarbazine	375	IV	1 and 15
stdBEACOPP/BEACOPP-14	Bleomycin	10	IV	8	14-21
	Etoposide	100	IV	1-3
	Doxorubicin	25	IV	1
	Cyclophosphamide	650	IV	1
	Vincristine†	1.4	IV	8
	Procarbazine	100	PO	1-7
	Prednisone‡	40-80	PO	1-14 or 1-7
	GCSF			9-13
escBEACOPP	Bleomycin	10	IV	8	21
	Etoposide	200	IV	1-3
	Doxorubicin	35	IV	1
	Cyclophosphamide	1200	IV	1
	Vincristine†	1.4	IV	8
	Procarbazine	100	PO	1-7
	Prednisone	40	PO	1-14
	GCSF			Day 9 until recovery

GCSF, granulocyte colony-stimulating factor; PO, oral administration; stdBEACOPP, standard BEACOPP. Other abbreviations are explained in Table 1.

Vinblastine is capped at 10 mg per administration.

Vincristine is capped at 2 mg per administration.

Prednisone is given as 40 mg from days 1 to 14 in stdBEACOPP and 80 mg from days 1 to 7 in BEACOPP-14.