Test characteristics for strategies to screen tumors of DLBCL morphology for FISH testing
| . | HGBL-DH/TH with BCL2 rearrangement . | HGBL-DH with BCL6 rearrangement . | Total HGBL-DH/TH . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic . | Frequency, n (%) . | Sens . | PPV . | Spec . | NPV . | Sens . | PPV . | Spec . | NPV . | Sens . | PPV . | Spec . | NPV . |
| COO: Lymph2Cx | |||||||||||||
| GCB | 549 (50) | 0.99 | 0.12 | 0.53 | 1.00 | 0.43 | 0.01 | 0.50 | 0.99 | 0.88 | 0.13 | 0.53 | 0.98 |
| GCB and UNC | 683 (62) | 1.00 | 0.10 | 0.40 | 1.00 | 0.50 | 0.01 | 0.38 | 0.98 | 0.92 | 0.11 | 0.40 | 0.98 |
| COO: Hans GCB | 612 (52) | 0.99 | 0.13 | 0.52 | 1.00 | 0.57 | 0.01 | 0.49 | 0.99 | 0.92 | 0.14 | 0.52 | 0.99 |
| DPE | 380 (34) | 0.75 | 0.14 | 0.69 | 0.98 | 0.53 | 0.02 | 0.66 | 0.99 | 0.70 | 0.16 | 0.69 | 0.96 |
| DPE/Lymph2Cx GCB | 128 (11) | 0.71 | 0.37 | 0.92 | 0.98 | 0.27 | 0.03 | 0.89 | 0.99 | 0.62 | 0.40 | 0.93 | 0.97 |
| DPE/Lymph2Cx GCB and UNC | 163 (14) | 0.73 | 0.30 | 0.89 | 0.98 | 0.33 | 0.03 | 0.86 | 0.99 | 0.65 | 0.33 | 0.89 | 0.97 |
| DPE/Hans GCB | 150 (13) | 0.73 | 0.35 | 0.91 | 0.98 | 0.29 | 0.03 | 0.87 | 0.99 | 0.65 | 0.38 | 0.91 | 0.97 |
| . | HGBL-DH/TH with BCL2 rearrangement . | HGBL-DH with BCL6 rearrangement . | Total HGBL-DH/TH . | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Characteristic . | Frequency, n (%) . | Sens . | PPV . | Spec . | NPV . | Sens . | PPV . | Spec . | NPV . | Sens . | PPV . | Spec . | NPV . |
| COO: Lymph2Cx | |||||||||||||
| GCB | 549 (50) | 0.99 | 0.12 | 0.53 | 1.00 | 0.43 | 0.01 | 0.50 | 0.99 | 0.88 | 0.13 | 0.53 | 0.98 |
| GCB and UNC | 683 (62) | 1.00 | 0.10 | 0.40 | 1.00 | 0.50 | 0.01 | 0.38 | 0.98 | 0.92 | 0.11 | 0.40 | 0.98 |
| COO: Hans GCB | 612 (52) | 0.99 | 0.13 | 0.52 | 1.00 | 0.57 | 0.01 | 0.49 | 0.99 | 0.92 | 0.14 | 0.52 | 0.99 |
| DPE | 380 (34) | 0.75 | 0.14 | 0.69 | 0.98 | 0.53 | 0.02 | 0.66 | 0.99 | 0.70 | 0.16 | 0.69 | 0.96 |
| DPE/Lymph2Cx GCB | 128 (11) | 0.71 | 0.37 | 0.92 | 0.98 | 0.27 | 0.03 | 0.89 | 0.99 | 0.62 | 0.40 | 0.93 | 0.97 |
| DPE/Lymph2Cx GCB and UNC | 163 (14) | 0.73 | 0.30 | 0.89 | 0.98 | 0.33 | 0.03 | 0.86 | 0.99 | 0.65 | 0.33 | 0.89 | 0.97 |
| DPE/Hans GCB | 150 (13) | 0.73 | 0.35 | 0.91 | 0.98 | 0.29 | 0.03 | 0.87 | 0.99 | 0.65 | 0.38 | 0.91 | 0.97 |
The test characteristics of other IHC markers and permutations are shown in supplemental Table 2.
NPV, negative predictive value; PPV, positive predictive value; sens, sensitivity; spec, specificity; UNC, unclassified DLBCL.