Definition of early-stage unfavorable disease by different study groups
| RF . | GHSG . | EORTC . | NCCN . | NCIC . |
|---|---|---|---|---|
| ESR and BSs* | >50 mm/h w/o BSs | >50 mm/h w/o BSs | >50 mm/h or any BSs | >50 mm/h or any BSs |
| >30 mm/h w/BSs | >30 mm/h w/BSs | |||
| LMM (>one-third of thoracic diameter) | Yes† | Yes | Yes | Yes |
| Nodal involvement | >2 nodal areas | >3 nodal areas | >3 nodal sites | >3 nodal sites |
| Bulky disease | — | — | >10 cm | >10 cm |
| Age | — | ≥50 y | — | ≥40 y |
| EN disease | Any EN† disease | — | — | — |
| Histology | — | — | — | MC or LD |
| RF . | GHSG . | EORTC . | NCCN . | NCIC . |
|---|---|---|---|---|
| ESR and BSs* | >50 mm/h w/o BSs | >50 mm/h w/o BSs | >50 mm/h or any BSs | >50 mm/h or any BSs |
| >30 mm/h w/BSs | >30 mm/h w/BSs | |||
| LMM (>one-third of thoracic diameter) | Yes† | Yes | Yes | Yes |
| Nodal involvement | >2 nodal areas | >3 nodal areas | >3 nodal sites | >3 nodal sites |
| Bulky disease | — | — | >10 cm | >10 cm |
| Age | — | ≥50 y | — | ≥40 y |
| EN disease | Any EN† disease | — | — | — |
| Histology | — | — | — | MC or LD |
Early-stage unfavorable disease defined as clinical stage I or II with ≥1 RF.
BS, B symptom; EN, extranodal; EORTC, European Organisation for Research and Treatment of Cancer; ESR, erythrocyte sedimentation rate; GHSG, German Hodgkin Study Group; LD, lymphocyte depletion; LMM, large mediastinal mass; MC, mixed cellularity; NCCN, National Comprehensive Cancer Network; NCIC: National Cancer Institute of Canada; w/, with; w/o, without.
For example, night sweats, weight loss, fever.
Stage IIB with the respective RF considered advanced-stage disease by the GHSG.