Clinical response to plasminogen (human)
| Patient* . | Sex . | Age (y) . | Lesion site . | Lesion assessment . | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline . | Wk 4 . | Wk 8 . | Wk 12 . | Wk 24 . | ||||
| 1 | F | 39 | Left eye | 10 mm × 2 mm | Resolved | Resolved | Resolved | Resolved |
| Right eye | 10 mm × 2 mm | Resolved | Resolved | Resolved | Resolved | |||
| Cervix | Present | Not assessed | Not assessed | Not assessed | Not assessed | |||
| 2 | M | 35 | Left eye | 15 mm × 5 mm | Resolved | Resolved | Resolved | Resolved |
| 4 | F | 24 | Upper gingiva | Nonmeasurable† | Resolved | Resolved | Resolved | Resolved |
| Bronchus | Present | Resolved | Resolved | Resolved | Resolved | |||
| 6 | F | 37 | Left eye | Nonmeasurable | Resolved | Resolved | Resolved | Resolved |
| Right eye | Nonmeasurable | Resolved | Resolved | Resolved | Resolved | |||
| Gingiva (5 locations) | Nonmeasurable | Resolved | Resolved | Resolved | Resolved | |||
| Right nares | Present‡ | Resolved | Resolved | Resolved | Resolved | |||
| Bronchus | Present | Not assessed | Not assessed | Improved | Improved | |||
| Renal | Present | Not assessed | Not assessed | Improved | Improved | |||
| 7 | F | 24 | Cervix | Present | Not assessed | Not assessed | Not assessed | Resolved |
| 8 | F | 5 | Right eye, lower lid | 10 mm × 5 mm | 1 mm × 1 mm | Resolved | Resolved | Resolved |
| Right eye, upper lid | 15 mm × 5 mm | 5 mm × 2 mm | 5 mm × 2 mm | Nonmeasurable§ | Resolved | |||
| Vagina | Present | Not assessed | Not assessed | Not assessed | Not assessed | |||
| 9 | F | 16 | Colon | Present | Not assessed | Not assessed | Resolved | Resolved |
| Vagina | Present | Not assessed | Not assessed | Resolved | Resolved | |||
| 10 | F | 11 | Left eye | 5 mm × 3 mm | Resolved | Resolved | Resolved | Resolved |
| Colon | Present | Not assessed | Not assessed | Not assessed | Not assessed | |||
| 12 | M | 33 | Left eye | 4 mm × 4 mm | 3 mm × 2 mm | Resolved | Resolved | NA |
| Right eye | 4 mm × 4 mm | 2 mm × 2 mm | Resolved | Resolved | NA | |||
| Lower gingiva | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Upper gingiva | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Acne|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Wounds/scars, hands|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Plantar warts, feet|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Palmar warts, hands|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| 13 | F | 33 | Left eye | 4 mm × 3 mm | 2 mm × 2 mm | 1.5 mm × 1.5 mm | Resolved | NA |
| Scar, right shoulder|| | Nonmeasurable | Unchanged | Unchanged | Improved | NA | |||
| Scar, right underarm|| | Nonmeasurable | Unchanged | Unchanged | Improved | NA | |||
| 14 | F | 42 | Left eye | Nonmeasurable | Improved | Improved | Resolved | NA |
| Right eye | Nonmeasurable | Improved | Improved | Resolved | NA | |||
| Lower gingiva | Nonmeasurable | Unchanged | Improved | Improved | NA | |||
| Upper gingiva | Nonmeasurable | Unchanged | Improved | Improved | NA | |||
| Tumors, wrists|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Palmar warts, hands|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Patient* . | Sex . | Age (y) . | Lesion site . | Lesion assessment . | ||||
|---|---|---|---|---|---|---|---|---|
| Baseline . | Wk 4 . | Wk 8 . | Wk 12 . | Wk 24 . | ||||
| 1 | F | 39 | Left eye | 10 mm × 2 mm | Resolved | Resolved | Resolved | Resolved |
| Right eye | 10 mm × 2 mm | Resolved | Resolved | Resolved | Resolved | |||
| Cervix | Present | Not assessed | Not assessed | Not assessed | Not assessed | |||
| 2 | M | 35 | Left eye | 15 mm × 5 mm | Resolved | Resolved | Resolved | Resolved |
| 4 | F | 24 | Upper gingiva | Nonmeasurable† | Resolved | Resolved | Resolved | Resolved |
| Bronchus | Present | Resolved | Resolved | Resolved | Resolved | |||
| 6 | F | 37 | Left eye | Nonmeasurable | Resolved | Resolved | Resolved | Resolved |
| Right eye | Nonmeasurable | Resolved | Resolved | Resolved | Resolved | |||
| Gingiva (5 locations) | Nonmeasurable | Resolved | Resolved | Resolved | Resolved | |||
| Right nares | Present‡ | Resolved | Resolved | Resolved | Resolved | |||
| Bronchus | Present | Not assessed | Not assessed | Improved | Improved | |||
| Renal | Present | Not assessed | Not assessed | Improved | Improved | |||
| 7 | F | 24 | Cervix | Present | Not assessed | Not assessed | Not assessed | Resolved |
| 8 | F | 5 | Right eye, lower lid | 10 mm × 5 mm | 1 mm × 1 mm | Resolved | Resolved | Resolved |
| Right eye, upper lid | 15 mm × 5 mm | 5 mm × 2 mm | 5 mm × 2 mm | Nonmeasurable§ | Resolved | |||
| Vagina | Present | Not assessed | Not assessed | Not assessed | Not assessed | |||
| 9 | F | 16 | Colon | Present | Not assessed | Not assessed | Resolved | Resolved |
| Vagina | Present | Not assessed | Not assessed | Resolved | Resolved | |||
| 10 | F | 11 | Left eye | 5 mm × 3 mm | Resolved | Resolved | Resolved | Resolved |
| Colon | Present | Not assessed | Not assessed | Not assessed | Not assessed | |||
| 12 | M | 33 | Left eye | 4 mm × 4 mm | 3 mm × 2 mm | Resolved | Resolved | NA |
| Right eye | 4 mm × 4 mm | 2 mm × 2 mm | Resolved | Resolved | NA | |||
| Lower gingiva | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Upper gingiva | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Acne|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Wounds/scars, hands|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Plantar warts, feet|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Palmar warts, hands|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| 13 | F | 33 | Left eye | 4 mm × 3 mm | 2 mm × 2 mm | 1.5 mm × 1.5 mm | Resolved | NA |
| Scar, right shoulder|| | Nonmeasurable | Unchanged | Unchanged | Improved | NA | |||
| Scar, right underarm|| | Nonmeasurable | Unchanged | Unchanged | Improved | NA | |||
| 14 | F | 42 | Left eye | Nonmeasurable | Improved | Improved | Resolved | NA |
| Right eye | Nonmeasurable | Improved | Improved | Resolved | NA | |||
| Lower gingiva | Nonmeasurable | Unchanged | Improved | Improved | NA | |||
| Upper gingiva | Nonmeasurable | Unchanged | Improved | Improved | NA | |||
| Tumors, wrists|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
| Palmar warts, hands|| | Nonmeasurable | Improved | Improved | Improved | NA | |||
F, female; M, male; NA, not available.
Patients 3, 5, and 11 did not have lesions present at baseline.
Clinically visible lesions that were too small to measure using the millimeter scale were described as nonmeasurable.
Lesion in the right nares was not accessed via photography; therefore, it was considered a nonvisible lesion.
Size of lesion decreased by 98% at week 12 to a point where it was no longer measurable using the millimeter scale.
Manifestations representing abnormal wound healing due to congenital plasminogen deficiency.