Table 1. Molecular characteristics of... | American Society of Hematology

Table 1.

Molecular characteristics of DLBCL cell lines

Cell line	DLBCL subtype	PTEN expression	Chronic active B-cell receptor signaling	Ibrutinib sensitivity	AZD8835 sensitivity	AZD5363 sensitivity	MYC aberrations
HBL-1	ABC	Yes	Yes²⁵	Yes*	Yes	No	Rearrangement⁴¹
OCI-Ly3	ABC	Yes	No²⁵	No*	No	No	Amplification⁴¹
OCI-Ly10	ABC	Yes	Yes²⁵	Yes²⁵	Yes	No	Amplification²⁰
TMD8	ABC	Yes	Yes²⁵	Yes*	Yes	No	n.a.
U2932	ABC	No	Yes²⁵	Yes*	Yes	Yes	n.a.
HT	GCB	No	n.a.	No*	No	Yes	n.a.
BJAB	GCB	No	No²⁵	No*	No	Yes	Amplification²⁰
OCI-Ly1	GCB	No	n.a.	No†	No	Yes	Amplification⁴²
OCI-Ly2	GCB	Yes	n.a.	No*	No	Yes	wt⁴²
OCI-Ly4	GCB	No	n.a.	No†	Yes	Yes	Rearrangement⁴²
OCI-Ly19	GCB	Yes	No²⁵	No²⁵	No	No	Rearrangement⁴³
K422	GCB	No	n.a.	No*	No	Yes	Rearrangement⁴⁴
SUDHL-4	GCB	Yes	n.a.	No†	No	Yes	Amplification⁴¹
DB	GCB	Yes	n.a.	n.a.	No	No	Amplification⁹
WSUDLCL2	GCB	No	n.a.	n.a.	No	Yes	Amplification⁴⁵

Cell line	DLBCL subtype	PTEN expression	Chronic active B-cell receptor signaling	Ibrutinib sensitivity	AZD8835 sensitivity	AZD5363 sensitivity	MYC aberrations
HBL-1	ABC	Yes	Yes²⁵	Yes*	Yes	No	Rearrangement⁴¹
OCI-Ly3	ABC	Yes	No²⁵	No*	No	No	Amplification⁴¹
OCI-Ly10	ABC	Yes	Yes²⁵	Yes²⁵	Yes	No	Amplification²⁰
TMD8	ABC	Yes	Yes²⁵	Yes*	Yes	No	n.a.
U2932	ABC	No	Yes²⁵	Yes*	Yes	Yes	n.a.
HT	GCB	No	n.a.	No*	No	Yes	n.a.
BJAB	GCB	No	No²⁵	No*	No	Yes	Amplification²⁰
OCI-Ly1	GCB	No	n.a.	No†	No	Yes	Amplification⁴²
OCI-Ly2	GCB	Yes	n.a.	No*	No	Yes	wt⁴²
OCI-Ly4	GCB	No	n.a.	No†	Yes	Yes	Rearrangement⁴²
OCI-Ly19	GCB	Yes	No²⁵	No²⁵	No	No	Rearrangement⁴³
K422	GCB	No	n.a.	No*	No	Yes	Rearrangement⁴⁴
SUDHL-4	GCB	Yes	n.a.	No†	No	Yes	Amplification⁴¹
DB	GCB	Yes	n.a.	n.a.	No	No	Amplification⁹
WSUDLCL2	GCB	No	n.a.	n.a.	No	Yes	Amplification⁴⁵

n.a., not available; wt, wild type.

Data shown in Figure 1A.

Data not shown.