Table 1.

Impact of DNMT3A, TET2, or any mutation on blood formula and biological parameters

End pointCovariatesTrans.MutationSEP% Change
WBC Age + smoking log10 DNMT3A 0.0142 0.0074 .055 3.33 
DNMT3A >10% 0.0123 0.0111 .269 2.87 
DNMT3A VAF continuous 0.0006 0.0004 .186 0.13 
TET2 −0.0178 0.0098 .070 −4.02 
TET2 >10% −0.0265 0.0128 .039 −5.92 
TET2 VAF continuous −0.0005 0.0005 .276 −0.11 
Any mutation 0.0035 0.0061 .565 0.81 
Any mutation >10% −0.0009 0.0084 .910 −0.22 
Hemoglobin Age + smoking None DNMT3A 0.3321 0.6645 .617 0.25 
DNMT3A >10% 1.8138 0.9933 .068 1.36 
DNMT3A VAF continuous 0.0624 0.0390 .110 NA 
TET2 −0.3903 0.8890 .661 −0.29 
TET2 >10% −0.9667 1.1561 .403 −0.73 
TET2 VAF continuous −0.0476 0.0411 .247 NA 
Any mutation 0.6235 0.5467 .254 0.47 
Any mutation >10% 1.1440 0.7468 .126 0.86 
Lymphocytes Age + smoking log10 DNMT3A 0.0085 0.0095 .371 1.97 
DNMT3A >10% 0.0099 0.0142 .486 2.30 
DNMT3A VAF continuous 0.0004 0.0006 .475 0.09 
TET2 −0.0038 0.0127 .763 −0.88 
TET2 >10% −0.0112 0.0165 .498 −2.54 
TET2 VAF continuous −0.0001 0.0006 .800 −0.03 
Any mutation 0.0071 0.0078 .364 1.65 
Any mutation >10% 0.0015 0.0107 .885 0.35 
Monocytes Age + smoking log10 DNMT3A 0.0061 0.0098 .535 1.42 
DNMT3A >10% 0.0068 0.0148 .644 1.59 
DNMT3A VAF continuous 0.0003 0.0006 .630 0.07 
TET2 0.0067 0.0132 .614 1.54 
TET2 >10% −0.0038 0.0172 .824 −0.88 
TET2 VAF continuous 0.0015 0.0006 .013 0.35 
Any mutation 0.0068 0.0082 .405 1.58 
Any mutation >10% 0.0038 0.0112 .737 0.87 
Neutrophils Age + smoking log10 DNMT3A 0.0183 0.0096 .057 4.30 
DNMT3A >10% 0.0122 0.0144 .397 2.84 
DNMT3A VAF continuous 0.0006 0.0006 .294 0.14 
TET2 −0.0303 0.0127 .017 −6.73 
TET2 >10% −0.0417 0.0166 .012 −9.15 
TET2 VAF continuous −0.0011 0.0006 .053 −0.26 
Any mutation 0.0007 0.0079 .929 0.16 
Any mutation >10% −0.0058 0.0108 .595 −1.32 
Platelets Age log10 DNMT3A 0.0014 0.0068 .831 0.33 
DNMT3A >10% −0.0022 0.0102 .827 −0.51 
DNMT3A VAF continuous −0.0002 0.0004 .702 −0.03 
TET2 −0.0124 0.0092 .175 −2.82 
TET2 >10% −0.0256 0.0120 .033 −5.73 
TET2 VAF continuous −0.0008 0.0005 .073 −0.19 
Any mutation 0.0032 0.0056 .572 0.73 
Any mutation >10% −0.0017 0.0077 .829 −0.38 
MCV Age + smoking none DNMT3A −0.0710 0.2686 .791 −0.08 
DNMT3A >10% −0.4800 0.4034 .234 −0.52 
DNMT3A VAF continuous −0.0118 0.0157 .455 NA 
TET2 −0.3377 0.3535 .340 −0.37 
TET2 >10% −0.7134 0.4616 .123 −0.78 
TET2 VAF continuous −0.0162 0.0163 .320 NA 
Any mutation −0.0263 0.2192 .905 −0.03 
Any mutation > 10% −0.3206 0.3011 .287 −0.35 
XCI ratio skewing Age none DNMT3A 0.0227 0.0114 .046 9.56 
DNMT3A >10% 0.0707 0.0169 3.10E-05 29.84 
DNMT3A VAF continuous 0.0026 0.0006 5.67E-05 NA 
TET2 0.0697 0.0144 1.55E-06 29.38 
TET2 >10% 0.0924 0.0187 9.55E-07 38.94 
TET2 VAF continuous 0.0034 0.0007 4.20E-07 NA 
Any mutation 0.0375 0.0092 4.76E-05 15.80 
Any mutation >10% 0.0746 0.0124 2.53E-09 31.42 
Telomere length Age log10 DNMT3A −0.0104 0.0096 .279 −2.37 
DNMT3A >10% −0.0155 0.0147 .292 −3.51 
DNMT3A VAF continuous −0.0008 0.0006 .143 −0.19 
TET2 −0.0254 0.0129 .049 −5.68 
TET2 >10% −0.0073 0.0172 .673 −1.66 
TET2 VAF continuous −0.0010 0.0007 .129 −0.23 
Any mutation −0.0205 0.0079 .010 −4.60 
Any mutation >10% −0.0196 0.0110 .076 −4.40 
End pointCovariatesTrans.MutationSEP% Change
WBC Age + smoking log10 DNMT3A 0.0142 0.0074 .055 3.33 
DNMT3A >10% 0.0123 0.0111 .269 2.87 
DNMT3A VAF continuous 0.0006 0.0004 .186 0.13 
TET2 −0.0178 0.0098 .070 −4.02 
TET2 >10% −0.0265 0.0128 .039 −5.92 
TET2 VAF continuous −0.0005 0.0005 .276 −0.11 
Any mutation 0.0035 0.0061 .565 0.81 
Any mutation >10% −0.0009 0.0084 .910 −0.22 
Hemoglobin Age + smoking None DNMT3A 0.3321 0.6645 .617 0.25 
DNMT3A >10% 1.8138 0.9933 .068 1.36 
DNMT3A VAF continuous 0.0624 0.0390 .110 NA 
TET2 −0.3903 0.8890 .661 −0.29 
TET2 >10% −0.9667 1.1561 .403 −0.73 
TET2 VAF continuous −0.0476 0.0411 .247 NA 
Any mutation 0.6235 0.5467 .254 0.47 
Any mutation >10% 1.1440 0.7468 .126 0.86 
Lymphocytes Age + smoking log10 DNMT3A 0.0085 0.0095 .371 1.97 
DNMT3A >10% 0.0099 0.0142 .486 2.30 
DNMT3A VAF continuous 0.0004 0.0006 .475 0.09 
TET2 −0.0038 0.0127 .763 −0.88 
TET2 >10% −0.0112 0.0165 .498 −2.54 
TET2 VAF continuous −0.0001 0.0006 .800 −0.03 
Any mutation 0.0071 0.0078 .364 1.65 
Any mutation >10% 0.0015 0.0107 .885 0.35 
Monocytes Age + smoking log10 DNMT3A 0.0061 0.0098 .535 1.42 
DNMT3A >10% 0.0068 0.0148 .644 1.59 
DNMT3A VAF continuous 0.0003 0.0006 .630 0.07 
TET2 0.0067 0.0132 .614 1.54 
TET2 >10% −0.0038 0.0172 .824 −0.88 
TET2 VAF continuous 0.0015 0.0006 .013 0.35 
Any mutation 0.0068 0.0082 .405 1.58 
Any mutation >10% 0.0038 0.0112 .737 0.87 
Neutrophils Age + smoking log10 DNMT3A 0.0183 0.0096 .057 4.30 
DNMT3A >10% 0.0122 0.0144 .397 2.84 
DNMT3A VAF continuous 0.0006 0.0006 .294 0.14 
TET2 −0.0303 0.0127 .017 −6.73 
TET2 >10% −0.0417 0.0166 .012 −9.15 
TET2 VAF continuous −0.0011 0.0006 .053 −0.26 
Any mutation 0.0007 0.0079 .929 0.16 
Any mutation >10% −0.0058 0.0108 .595 −1.32 
Platelets Age log10 DNMT3A 0.0014 0.0068 .831 0.33 
DNMT3A >10% −0.0022 0.0102 .827 −0.51 
DNMT3A VAF continuous −0.0002 0.0004 .702 −0.03 
TET2 −0.0124 0.0092 .175 −2.82 
TET2 >10% −0.0256 0.0120 .033 −5.73 
TET2 VAF continuous −0.0008 0.0005 .073 −0.19 
Any mutation 0.0032 0.0056 .572 0.73 
Any mutation >10% −0.0017 0.0077 .829 −0.38 
MCV Age + smoking none DNMT3A −0.0710 0.2686 .791 −0.08 
DNMT3A >10% −0.4800 0.4034 .234 −0.52 
DNMT3A VAF continuous −0.0118 0.0157 .455 NA 
TET2 −0.3377 0.3535 .340 −0.37 
TET2 >10% −0.7134 0.4616 .123 −0.78 
TET2 VAF continuous −0.0162 0.0163 .320 NA 
Any mutation −0.0263 0.2192 .905 −0.03 
Any mutation > 10% −0.3206 0.3011 .287 −0.35 
XCI ratio skewing Age none DNMT3A 0.0227 0.0114 .046 9.56 
DNMT3A >10% 0.0707 0.0169 3.10E-05 29.84 
DNMT3A VAF continuous 0.0026 0.0006 5.67E-05 NA 
TET2 0.0697 0.0144 1.55E-06 29.38 
TET2 >10% 0.0924 0.0187 9.55E-07 38.94 
TET2 VAF continuous 0.0034 0.0007 4.20E-07 NA 
Any mutation 0.0375 0.0092 4.76E-05 15.80 
Any mutation >10% 0.0746 0.0124 2.53E-09 31.42 
Telomere length Age log10 DNMT3A −0.0104 0.0096 .279 −2.37 
DNMT3A >10% −0.0155 0.0147 .292 −3.51 
DNMT3A VAF continuous −0.0008 0.0006 .143 −0.19 
TET2 −0.0254 0.0129 .049 −5.68 
TET2 >10% −0.0073 0.0172 .673 −1.66 
TET2 VAF continuous −0.0010 0.0007 .129 −0.23 
Any mutation −0.0205 0.0079 .010 −4.60 
Any mutation >10% −0.0196 0.0110 .076 −4.40 

Correction for multiple testing (P < .0024).

⁠, standardized regression coefficient; MCV, mean corpuscular volume; NA, not applicable; SE, standard error; Trans., transformation.

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