Infection and the egress rates of mature schizont isolated from cultures treated with R406 (1.0 and 2.5 μM)
| . | Control . | [R406] (1 µM) . | [R406] (2.5 µM) . | |||
|---|---|---|---|---|---|---|
| . | No shear stress . | Shear stress . | No shear stress . | Shear stress . | No shear stress . | Shear Stress . |
| Infection rate | 3.48 ± 0.96 | 4.24 ± 1.21 | 0.63 ± 0.25 | 2.6 ± 0.83 | 0.13 ± 0.06 | 0.30 ± 0.39 |
| Egress rate | 6.60 ± 2.41 | 9.37 ± 3.10 | 1.12 ± 0.84 | 3.9 ± 1.11 | 0.27 ± 0.48 | 1.09 ± 1.16 |
| . | Control . | [R406] (1 µM) . | [R406] (2.5 µM) . | |||
|---|---|---|---|---|---|---|
| . | No shear stress . | Shear stress . | No shear stress . | Shear stress . | No shear stress . | Shear Stress . |
| Infection rate | 3.48 ± 0.96 | 4.24 ± 1.21 | 0.63 ± 0.25 | 2.6 ± 0.83 | 0.13 ± 0.06 | 0.30 ± 0.39 |
| Egress rate | 6.60 ± 2.41 | 9.37 ± 3.10 | 1.12 ± 0.84 | 3.9 ± 1.11 | 0.27 ± 0.48 | 1.09 ± 1.16 |
A portion of the schizonts were subjected to a rapid shear stress treatment to test its effect on the infection and egress rates. Results are the mean of 3 independent experiments (± SD) and expressed as number of released merozoites (egress rate) or number of infected RBC (infection rate) per each schizont present in the culture (no shear stress/shear stress).
Infection rate, RBC infected per schizont; egress rate, merozoites released per schizont.