Clinical, echocardiographic, and CMR characteristics of study participants based on ECV
| Characteristic . | ECV <0.40 (N = 9) . | ECV ≥0.40 (N = 16) . | P . |
|---|---|---|---|
| Age, y | 21.4 ± 8 | 23.8 ± 16 | .68 |
| Female, n (%) | 4 (44) | 10 (63) | .43 |
| Receiving hydroxyurea, n (%) | 5 (56) | 14 (88) | .14 |
| Normal diastolic function, n (%) | 6 (67) | 1 (6) | .003 |
| TRV, m/s | 2.4 ± 0.4 | 2.5 ± 0.6 | .83 |
| Tricuspid E/A ratio | 1.9 ± 0.3 | 1.4 ± 0.4 | .006 |
| Tricuspid E/e′ ratio | 8.4 ± 2.4 | 8.3 ± 2.2 | .93 |
| Hemoglobin, g/dL | 10.6 ± 1.4 | 9.3 ± 1.4 | .02 |
| Reticulocyte count, % | 6 ± 2.5 | 9.6 ± 5.9 | .08 |
| NT-proBNP, pg/mL | 38 ± 40 | 177 ± 216 | .005 |
| Native T1, ms | 960 ± 56 | 1034 ± 58 | .005 |
| ECV | 0.36 ± 0.02 | 0.49 ± 0.06 | <.0001 |
| LAVi, mL/m2 | 54 ± 15 | 65 ± 13 | .04 |
| LVEDVi, mL/m2 | 99 ± 22 | 118 ± 22 | .057 |
| LVESV index, mL/m2 | 38 ± 10 | 47 ± 14 | .11 |
| LVSVi index, mL/m2 | 59 ± 15 | 71 ± 12 | .04 |
| LVEF, % | 62 ± 4 | 61 ± 6 | .54 |
| LVMi, g/m2 | 59 ± 15 | 70 ± 19 | .16 |
| RVEDVi, mL/m2 | 103 ± 24 | 118 ± 25 | .17 |
| RVESV, mL/m2 | 42 ± 11 | 50 ± 16 | .19 |
| RVSV index, mL/m2 | 62 ± 14 | 68 ± 13 | .25 |
| RVEF, % | 60 ± 4 | 58 ± 6 | .50 |
| LV cardiac index, L/min per m2 | 4.7 ± 0.9 | 5.2 ± 1.4 | .31 |
| RV cardiac index, L/min per m2 | 4.7 ± 1 | 4.7 ± 1.8 | .92 |
| Characteristic . | ECV <0.40 (N = 9) . | ECV ≥0.40 (N = 16) . | P . |
|---|---|---|---|
| Age, y | 21.4 ± 8 | 23.8 ± 16 | .68 |
| Female, n (%) | 4 (44) | 10 (63) | .43 |
| Receiving hydroxyurea, n (%) | 5 (56) | 14 (88) | .14 |
| Normal diastolic function, n (%) | 6 (67) | 1 (6) | .003 |
| TRV, m/s | 2.4 ± 0.4 | 2.5 ± 0.6 | .83 |
| Tricuspid E/A ratio | 1.9 ± 0.3 | 1.4 ± 0.4 | .006 |
| Tricuspid E/e′ ratio | 8.4 ± 2.4 | 8.3 ± 2.2 | .93 |
| Hemoglobin, g/dL | 10.6 ± 1.4 | 9.3 ± 1.4 | .02 |
| Reticulocyte count, % | 6 ± 2.5 | 9.6 ± 5.9 | .08 |
| NT-proBNP, pg/mL | 38 ± 40 | 177 ± 216 | .005 |
| Native T1, ms | 960 ± 56 | 1034 ± 58 | .005 |
| ECV | 0.36 ± 0.02 | 0.49 ± 0.06 | <.0001 |
| LAVi, mL/m2 | 54 ± 15 | 65 ± 13 | .04 |
| LVEDVi, mL/m2 | 99 ± 22 | 118 ± 22 | .057 |
| LVESV index, mL/m2 | 38 ± 10 | 47 ± 14 | .11 |
| LVSVi index, mL/m2 | 59 ± 15 | 71 ± 12 | .04 |
| LVEF, % | 62 ± 4 | 61 ± 6 | .54 |
| LVMi, g/m2 | 59 ± 15 | 70 ± 19 | .16 |
| RVEDVi, mL/m2 | 103 ± 24 | 118 ± 25 | .17 |
| RVESV, mL/m2 | 42 ± 11 | 50 ± 16 | .19 |
| RVSV index, mL/m2 | 62 ± 14 | 68 ± 13 | .25 |
| RVEF, % | 60 ± 4 | 58 ± 6 | .50 |
| LV cardiac index, L/min per m2 | 4.7 ± 0.9 | 5.2 ± 1.4 | .31 |
| RV cardiac index, L/min per m2 | 4.7 ± 1 | 4.7 ± 1.8 | .92 |
Values are presented as mean ± standard deviation unless otherwise indicated. P values were calculated using the Student t test, Mann-Whitney U test, or Fisher’s exact test as appropriate. Statistically significant measurements are shown in bold. The abbreviations used are defined in Table 2.