Baseline clinical and laboratory characteristics of study participants
| Characteristic . | Value . |
|---|---|
| Age, mean ± SD (range), y | 23 ± 13 (6-61) |
| Female, n (%) | 14 (56) |
| Receiving hydroxyurea, n (%) | 19 (76) |
| Heart rate, bpm | 78 ± 12 |
| Systolic blood pressure, mmHg | 125 ± 16 |
| Diastolic blood pressure, mmHg | 63 ± 9 |
| White blood cell count, 103/mm3 | 9.5 ± 3.4 |
| Hemoglobin, g/dL | 9.7 ± 1.5 |
| Hematocrit, % | 27.7 ± 4.2 |
| Reticulocyte count, % | 8.3 ± 5.2 |
| Platelet count, 103/mm3 | 341 ± 94 |
| Bilirubin, mg/dL | 2.4 ± 1.5 |
| AST, U/L | 48 ± 28 |
| LDH, U/L | 556 ± 267 |
| Plasma free hemoglobin, mg/dL | 75.3 ± 102 |
| Nucleated RBC, cell/100 WBC | 6.2 ± 17 |
| Fetal hemoglobin, % | 17.8 ± 12.5 |
| Mean corpuscular volume, fL | 94.3 ± 19 |
| Absolute neutrophil count, K/μL | 4.9 ± 2.5 |
| Creatinine, mg/dL | 0.58 ± 0.2 |
| Cystatin C, mg/L | 0.67 ± 0.18 |
| GFR, mL/min per 1.73 m2 | 139.7 ± 38 |
| Aldosterone, ng/dL | 8.8 ± 6.1 |
| Plasma renin activity, ng/mL per hour | 1.86 ± 1.4 |
| NT-proBNP, pg/mL | 127.1 ± 182.8 |
| Characteristic . | Value . |
|---|---|
| Age, mean ± SD (range), y | 23 ± 13 (6-61) |
| Female, n (%) | 14 (56) |
| Receiving hydroxyurea, n (%) | 19 (76) |
| Heart rate, bpm | 78 ± 12 |
| Systolic blood pressure, mmHg | 125 ± 16 |
| Diastolic blood pressure, mmHg | 63 ± 9 |
| White blood cell count, 103/mm3 | 9.5 ± 3.4 |
| Hemoglobin, g/dL | 9.7 ± 1.5 |
| Hematocrit, % | 27.7 ± 4.2 |
| Reticulocyte count, % | 8.3 ± 5.2 |
| Platelet count, 103/mm3 | 341 ± 94 |
| Bilirubin, mg/dL | 2.4 ± 1.5 |
| AST, U/L | 48 ± 28 |
| LDH, U/L | 556 ± 267 |
| Plasma free hemoglobin, mg/dL | 75.3 ± 102 |
| Nucleated RBC, cell/100 WBC | 6.2 ± 17 |
| Fetal hemoglobin, % | 17.8 ± 12.5 |
| Mean corpuscular volume, fL | 94.3 ± 19 |
| Absolute neutrophil count, K/μL | 4.9 ± 2.5 |
| Creatinine, mg/dL | 0.58 ± 0.2 |
| Cystatin C, mg/L | 0.67 ± 0.18 |
| GFR, mL/min per 1.73 m2 | 139.7 ± 38 |
| Aldosterone, ng/dL | 8.8 ± 6.1 |
| Plasma renin activity, ng/mL per hour | 1.86 ± 1.4 |
| NT-proBNP, pg/mL | 127.1 ± 182.8 |
Values are shown as mean ± standard deviation unless otherwise specified.
AST, aspartate aminotransferase; GFR, glomerular filtration rate; LDH, lactate dehydrogenase; RBC, red blood cell; SD, standard deviation; WBC, white blood cell.