Table 1. Association of THBD SNPs with... | American Society of Hematology

Table 1.

Association of THBD SNPs with incident VTE, ARIC study, 1987 to 2011

VTEs, n	SNP	Minor allele	Minor allele frequency	r²*	Additive model†		Dominant model‡
VTEs, n	SNP	Minor allele	Minor allele frequency	r²*	HR (95% CI)	P	HR (95% CI)	P
177	rs2144940	C	0.24	0.97	0.81 (0.62-1.05)	.10	0.76 (0.56-1.03)	.08
177	rs2567617	G	0.23	0.97	0.80 (0.61-1.04)	.10	0.76 (0.56-1.04)	.08
180	rs1998081	T	0.20	0.98	0.77 (0.58-1.02)	.07	0.71 (0.51-0.98)	.04

VTEs, n	SNP	Minor allele	Minor allele frequency	r²*	Additive model†		Dominant model‡
VTEs, n	SNP	Minor allele	Minor allele frequency	r²*	HR (95% CI)	P	HR (95% CI)	P
177	rs2144940	C	0.24	0.97	0.81 (0.62-1.05)	.10	0.76 (0.56-1.03)	.08
177	rs2567617	G	0.23	0.97	0.80 (0.61-1.04)	.10	0.76 (0.56-1.04)	.08
180	rs1998081	T	0.20	0.98	0.77 (0.58-1.02)	.07	0.71 (0.51-0.98)	.04

HRs are adjusted for age, sex, center, and first 4 principal components of ancestry.

CI, confidence interval.

r² is a measure of imputation quality ranging from 0 to 1, with 1 being the highest accuracy.

Modeled per 1-copy increment in minor allele dose.

Modeled as carrier of the minor allele vs no carrier.