Summary of SIT and CSSCD cohort demographics and clinical characteristics
| Characteristic . | CSSCD (n = 349)* . | SIT trial (n = 934)† . | P‡ . |
|---|---|---|---|
| Male sex, n (%) | 195 (54.3) | 489 (52.3) | .53 |
| Age, mean ± SD, y | 6.92 ± 2.78 | 8.96 ± 2.44 | <.001 |
| Follow-up, mean ± SD, y | 2.8 ± 0.67 | 3.00 ± 0.0 | <.001 |
| Acute, severe vaso-occlusive pain rate (events per patient year)§ | 0.58 ± 1.02 | 0.61 ± 0.83 | .01 |
| ACS rate (events per patient year) | 0.18 ± 0.41 | 0.13 ± 0.26 | .14 |
| Hematocrit, mean ± SD, % | 23.10 ± 2.81 | 23.35 ± 3.43 | .47 |
| Hemoglobin, mean ± SD, g/dL | 7.98 ± 0.88 | 8.12 ± 1.08 | .15 |
| Fetal hemoglobin, mean ± SD, % | 7.59 ± 4.87 | 8.94 ± 5.75 | .001 |
| Reticulocytes, mean ± SD, % | 13.99 ± 5.62 | 12.02 ± 5.48 | <.001 |
| White blood cells, ×109/L | 12.38 ± 2.71 | 12.58 ± 5.26 | .68 |
| Characteristic . | CSSCD (n = 349)* . | SIT trial (n = 934)† . | P‡ . |
|---|---|---|---|
| Male sex, n (%) | 195 (54.3) | 489 (52.3) | .53 |
| Age, mean ± SD, y | 6.92 ± 2.78 | 8.96 ± 2.44 | <.001 |
| Follow-up, mean ± SD, y | 2.8 ± 0.67 | 3.00 ± 0.0 | <.001 |
| Acute, severe vaso-occlusive pain rate (events per patient year)§ | 0.58 ± 1.02 | 0.61 ± 0.83 | .01 |
| ACS rate (events per patient year) | 0.18 ± 0.41 | 0.13 ± 0.26 | .14 |
| Hematocrit, mean ± SD, % | 23.10 ± 2.81 | 23.35 ± 3.43 | .47 |
| Hemoglobin, mean ± SD, g/dL | 7.98 ± 0.88 | 8.12 ± 1.08 | .15 |
| Fetal hemoglobin, mean ± SD, % | 7.59 ± 4.87 | 8.94 ± 5.75 | .001 |
| Reticulocytes, mean ± SD, % | 13.99 ± 5.62 | 12.02 ± 5.48 | <.001 |
| White blood cells, ×109/L | 12.38 ± 2.71 | 12.58 ± 5.26 | .68 |
ACS, acute chest syndrome.
Age range at enrollment was 2 to 12 years; pain/ACS events were defined as those occurring 3 years prospectively from date of enrollment; therefore, the age range in which they developed pain is 2 to 15 years.
Age range was 2 to 15 years at enrollment; pain/ACS events were defined as those occurring within 3 years retrospectively (from the date of enrollement); the youngest patient included was 5 years of age.
P values for continuous and categorical variables are based on Wilcoxon rank-sum test (with continuity correction) and Pearson’s χ2 test, respectively.
Acute, severe vaso-occlusive pain was defined as an acute episode of pain requiring hospitalization and treatment with opioids.