Primary and secondary platelet count increment outcomes
| Outcome . | Phenotype of platelet donor . | |||
|---|---|---|---|---|
| Unselected (n = 28) . | High responder (n = 49) . | Low-responder platelets (n = 51) . | ||
| Difference from unselected group . | Difference from unselected group . | Difference from high-responder group . | ||
| Platelet increment at 1 h, mean (SE) | 24.00 (1.96) | 22.96 (1.54) | 22.39 (1.25) | |
| Difference in means (95% CI) | NA | −2.20 (−6.15, 1.75)* | −0.15 (−4.31, 4.02)* | 2.30 (−1.09, 5.69)† |
| P | NA | .28* | .95* | .18† |
| Platelet increment at 24 h, mean (SE) | 15.61 (1.75) | 14.87 (1.42) | 13.74 (1.27) | |
| Difference in means (95% CI) | NA | −2.06 (−5.72, 1.59)* | −0.93 (−4.82, 2.96)* | 1.41 (−1.96, 4.78)† |
| P | NA | .27* | .64* | .41† |
| CCI at 1 h, mean (SE) | 17.13 (1.22) | 16.26 (0.84) | 17.29 (0.84) | |
| Difference in means (95% CI) | NA | −1.46 (−4.13, 1.22)‡ | −0.12 (−2.84, 2.60)‡ | 1.36 (−0.89, 3.61)§ |
| P | NA | .29‡ | .93‡ | .24§ |
| CCI at 24 h, mean (SE) | 11.01 (1.08) | 10.51 (0.88) | 10.40 (0.86) | |
| Difference in means (95% CI) | NA | −1.12 (−3.69, 1.44)‡ | −1.02 (−3.54, 1.49)‡ | 0.13 (−2.18, 2.44)§ |
| P | NA | .39‡ | .43‡ | .91§ |
| Outcome . | Phenotype of platelet donor . | |||
|---|---|---|---|---|
| Unselected (n = 28) . | High responder (n = 49) . | Low-responder platelets (n = 51) . | ||
| Difference from unselected group . | Difference from unselected group . | Difference from high-responder group . | ||
| Platelet increment at 1 h, mean (SE) | 24.00 (1.96) | 22.96 (1.54) | 22.39 (1.25) | |
| Difference in means (95% CI) | NA | −2.20 (−6.15, 1.75)* | −0.15 (−4.31, 4.02)* | 2.30 (−1.09, 5.69)† |
| P | NA | .28* | .95* | .18† |
| Platelet increment at 24 h, mean (SE) | 15.61 (1.75) | 14.87 (1.42) | 13.74 (1.27) | |
| Difference in means (95% CI) | NA | −2.06 (−5.72, 1.59)* | −0.93 (−4.82, 2.96)* | 1.41 (−1.96, 4.78)† |
| P | NA | .27* | .64* | .41† |
| CCI at 1 h, mean (SE) | 17.13 (1.22) | 16.26 (0.84) | 17.29 (0.84) | |
| Difference in means (95% CI) | NA | −1.46 (−4.13, 1.22)‡ | −0.12 (−2.84, 2.60)‡ | 1.36 (−0.89, 3.61)§ |
| P | NA | .29‡ | .93‡ | .24§ |
| CCI at 24 h, mean (SE) | 11.01 (1.08) | 10.51 (0.88) | 10.40 (0.86) | |
| Difference in means (95% CI) | NA | −1.12 (−3.69, 1.44)‡ | −1.02 (−3.54, 1.49)‡ | 0.13 (−2.18, 2.44)§ |
| P | NA | .39‡ | .43‡ | .91§ |
NA, not applicable; SE, standard error.
Taken from a linear mixed-effects model on both 1 and 24 h time points with the unselected group as reference, adjusted for BSA, the platelet dose transfused, and age of platelets transfused.
Taken from a linear mixed-effects model on both 1 and 24 h time points with the high-responder group as reference, adjusted for BSA, the platelet dose transfused, and age of platelets transfused.
Taken from a linear mixed-effects model on both 1 and 24 h time points with the unselected group as reference, adjusted for age of platelets transfused.
Taken from a linear mixed-effects model on both 1 and 24 h time points with the high-responder group as reference, adjusted for age of platelets transfused.