Table 1. Target antigens that have been... | American Society of Hematology

Table 1.

Target antigens that have been considered for CAR-T therapies of MM

Antigen	Expression in nonmalignant cells	Expression in MM	Clinical trial of CAR-Ts in myeloma	References
CD44v6	Activated T cells, activated monocytes, keratinocytes	Reported to be expressed by 43% of advanced MM cases	No	62, 63
CD70	Activated lymphoid cells	Only a portion of the myeloma cells express CD70 in most cases	No	64, 66
CD56	NK cells, T cells, neuronal cells	Strongly expressed in 70% of patients with myeloma	No	67, 68, 70
CD38	Precursor B cells, plasma cells, T cells, NK cells, myeloid precursors, prostate cells, nervous system, osteoclasts, muscle cells	Strong, uniform expression on myeloma cells	No	72, 78, 79
CD138	Plasma cells, salivary glands, liver, skin	Expressed on MM cells	Yes	36, 81, 82
CD19	B cells	Minimal expression of CD19 on myeloma plasma cell surface. CD19⁺ cells may represent cancer stem cell in MM	Yes	10, 35, 59, 84
Immunoglobulin κ light chain	Mature B cells	Potential target on B cells that represent MM stem cells and that express surface immunoglobulins	Yes	21, 85
SLAMF7	Plasma cells, NK cells, CD8⁺ cells, activated monocytes and B cells, dendritic cells	Strongly expressed by MM cells	No	88, 89
BCMA	Plasma cells, small subset of B cells	Expressed on MM cells	Yes	9, 20, 37, 95, 96, 102, 103

Antigen	Expression in nonmalignant cells	Expression in MM	Clinical trial of CAR-Ts in myeloma	References
CD44v6	Activated T cells, activated monocytes, keratinocytes	Reported to be expressed by 43% of advanced MM cases	No	62, 63
CD70	Activated lymphoid cells	Only a portion of the myeloma cells express CD70 in most cases	No	64, 66
CD56	NK cells, T cells, neuronal cells	Strongly expressed in 70% of patients with myeloma	No	67, 68, 70
CD38	Precursor B cells, plasma cells, T cells, NK cells, myeloid precursors, prostate cells, nervous system, osteoclasts, muscle cells	Strong, uniform expression on myeloma cells	No	72, 78, 79
CD138	Plasma cells, salivary glands, liver, skin	Expressed on MM cells	Yes	36, 81, 82
CD19	B cells	Minimal expression of CD19 on myeloma plasma cell surface. CD19⁺ cells may represent cancer stem cell in MM	Yes	10, 35, 59, 84
Immunoglobulin κ light chain	Mature B cells	Potential target on B cells that represent MM stem cells and that express surface immunoglobulins	Yes	21, 85
SLAMF7	Plasma cells, NK cells, CD8⁺ cells, activated monocytes and B cells, dendritic cells	Strongly expressed by MM cells	No	88, 89
BCMA	Plasma cells, small subset of B cells	Expressed on MM cells	Yes	9, 20, 37, 95, 96, 102, 103

BCMA, B-cell maturation antigen; NK, natural killer; SLAMF7, signaling lymphocyte–activating molecule F7.