Table 2.

Anti-CD20 mAbs in development

NameCompanyType (all IgG1κ)Status
Rituximab Roche/Genentech Chimeric Approved 
Ofatumumab Novartis Fully human Approved 
Obinutuzumab Roche/Genentech Humanized, glycoengineered Approved 
Ublituximab TG Therapeutics Chimeric, glycoengineered Phase 3 
Veltuzumab Immunomedics Humanized Phase 2 
Ocaratuzumab Mentrik Biotech Humanized, Fc mutant Apparently stopped 
Ocrelizumab Roche/Genentech Humanized Stopped in hematology 
PRO131921 Roche/Genentech Humanized, Fc mutant Stopped 
NameCompanyType (all IgG1κ)Status
Rituximab Roche/Genentech Chimeric Approved 
Ofatumumab Novartis Fully human Approved 
Obinutuzumab Roche/Genentech Humanized, glycoengineered Approved 
Ublituximab TG Therapeutics Chimeric, glycoengineered Phase 3 
Veltuzumab Immunomedics Humanized Phase 2 
Ocaratuzumab Mentrik Biotech Humanized, Fc mutant Apparently stopped 
Ocrelizumab Roche/Genentech Humanized Stopped in hematology 
PRO131921 Roche/Genentech Humanized, Fc mutant Stopped 

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