Table summarizing BRAFV600E mutant allele frequency among blood monocytes and myeloid DCs (data from Figure 3) and the potential of WT cells to form langerinhigh LCH-like cells or foamy macrophages in vitro
| . | CD14 . | CD16 . | CD1c . |
|---|---|---|---|
| % BRAFV600E | |||
| Median | 0.38 | 1.36 | 0.2 |
| Range | 0-18 | 0-45 | 0-8 |
| Langerin+potential | |||
| GM-CSF + TGF-β | − | − | ++ |
| +DLL1 | + | − | +++ |
| +DLL4 | +++ | − | +++ |
| Foamy mac potential | +++ | +++ | − |
| . | CD14 . | CD16 . | CD1c . |
|---|---|---|---|
| % BRAFV600E | |||
| Median | 0.38 | 1.36 | 0.2 |
| Range | 0-18 | 0-45 | 0-8 |
| Langerin+potential | |||
| GM-CSF + TGF-β | − | − | ++ |
| +DLL1 | + | − | +++ |
| +DLL4 | +++ | − | +++ |
| Foamy mac potential | +++ | +++ | − |
Frequency of langerinhigh indicated as follows: −, <10%; +, 10%-25%; ++, 26%-35%; +++, >35%.