Hematologic and organ response assessment at 6 months in the low-dFLC cohort in the subset of patients with baseline dFLC <20 mg/L
| . | Hematologic response, n (%) . | Cardiac response, n (%) . | Renal response, n (%) . | Overall survival at 5 y, % . | Renal survival at 3 y, % . |
|---|---|---|---|---|---|
| CR | 20 (21) | 4/7 (57) | 3/16 (18) | 93 | 97 |
| Low dFLC PR | 38 (39) | 6/17 (35) | 5/30 (16) | 93 | 96 |
| No response | 38 (60) | 4/21 (19) | 1/39 (2) | 57 | 76 |
| . | Hematologic response, n (%) . | Cardiac response, n (%) . | Renal response, n (%) . | Overall survival at 5 y, % . | Renal survival at 3 y, % . |
|---|---|---|---|---|---|
| CR | 20 (21) | 4/7 (57) | 3/16 (18) | 93 | 97 |
| Low dFLC PR | 38 (39) | 6/17 (35) | 5/30 (16) | 93 | 96 |
| No response | 38 (60) | 4/21 (19) | 1/39 (2) | 57 | 76 |
Cardiac response is defined as a decrease in NT-pro-BNP >30% and >300 ng/L (in patients with a baseline NT-pro-BNP >650 ng/L). Renal response required a decrease in proteinuria >30% or <0.5 g per 24 hours in the absence of renal progression (decrease in estimated glomerular filtration rate ≥25%). Low dFLC PR indicates a reduction of dFLC <10 mg/L.