Multivariable proportional hazards models incorporating dFLC
| . | Overall survival (985 cases, 503 events) . | P . | Renal survival* (670 cases, 90 events) . | P . |
|---|---|---|---|---|
| dFLC <50 mg/L | 0.44 (0.31-0.64) | <.001 | 0.83 (0.54-1.28) | .403 |
| Mayo stage II vs I | 2.67 (1.86-3.82) | <.001 | Not included | — |
| Mayo stage III vs I | 5.56 (3.84-8.03) | <.001 | Not included | — |
| Renal stage II vs I | Not included | — | 16.9 (2.33-122.2) | <.001 |
| Renal stage III vs I | Not included | — | 38.6 (5.30-280.1) | <.001 |
| . | Overall survival (985 cases, 503 events) . | P . | Renal survival* (670 cases, 90 events) . | P . |
|---|---|---|---|---|
| dFLC <50 mg/L | 0.44 (0.31-0.64) | <.001 | 0.83 (0.54-1.28) | .403 |
| Mayo stage II vs I | 2.67 (1.86-3.82) | <.001 | Not included | — |
| Mayo stage III vs I | 5.56 (3.84-8.03) | <.001 | Not included | — |
| Renal stage II vs I | Not included | — | 16.9 (2.33-122.2) | <.001 |
| Renal stage III vs I | Not included | — | 38.6 (5.30-280.1) | <.001 |
Mayo stage is based on NT-pro-BNP >332 ng/L and troponin I >0.1 ng/mL. Renal stage is based on proteinuria 5 g per 24 hours and estimated glomerular filtration rate 50 mL/min per 1.73 m2.
dFLC, difference between involved and uninvolved free light chains.
Only in patients with renal involvement.