Characterization of fever in patients who develop CRS
| Fever . | CRS grade . | P* . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-3 . | 4-5 . | Total . | |||||||||||
| No. . | Median . | IQR . | Range . | No. . | Median . | IQR . | Range . | No. . | Median . | IQR . | Range . | ||
| No. of patients | 83 | 10 | 92 | ||||||||||
| Fever onset (days after CAR T-cell infusion) | 3.9 | 0.8-5.6 | 0.1-19 | 0.4 | 0.3-0.9 | 0.2-1.0 | 2.2 | 0.9-5.6 | 0.1-19 | <.0001 | |||
| Time to peak temperature (days after CAR T-cell infusion) | 5.7 | 4.3-7.6 | 0.2-30 | 2.8 | 1.3-3.2 | 0.4-11 | 5.3 | 3.4-7.3 | 0.2-30 | .001 | |||
| Maximum temperature (°C) | 39.4 | 39.2-39.6 | 37.7-41.3 | 40.4 | 40.1-40.6 | 39.9-40.9 | 39.5 | 39.2-39.8 | 37.7-41.3 | <.0001 | |||
| Fever duration (days after first fever) | 2.5 | 1.2-4.7 | 0.02-15 | 4.4 | 3.6-5.4 | 3.1-6.8 | 3.0 | 1.2-4.8 | 0.02-15 | .03 | |||
| Fever . | CRS grade . | P* . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1-3 . | 4-5 . | Total . | |||||||||||
| No. . | Median . | IQR . | Range . | No. . | Median . | IQR . | Range . | No. . | Median . | IQR . | Range . | ||
| No. of patients | 83 | 10 | 92 | ||||||||||
| Fever onset (days after CAR T-cell infusion) | 3.9 | 0.8-5.6 | 0.1-19 | 0.4 | 0.3-0.9 | 0.2-1.0 | 2.2 | 0.9-5.6 | 0.1-19 | <.0001 | |||
| Time to peak temperature (days after CAR T-cell infusion) | 5.7 | 4.3-7.6 | 0.2-30 | 2.8 | 1.3-3.2 | 0.4-11 | 5.3 | 3.4-7.3 | 0.2-30 | .001 | |||
| Maximum temperature (°C) | 39.4 | 39.2-39.6 | 37.7-41.3 | 40.4 | 40.1-40.6 | 39.9-40.9 | 39.5 | 39.2-39.8 | 37.7-41.3 | <.0001 | |||
| Fever duration (days after first fever) | 2.5 | 1.2-4.7 | 0.02-15 | 4.4 | 3.6-5.4 | 3.1-6.8 | 3.0 | 1.2-4.8 | 0.02-15 | .03 | |||
Two-sided P values were calculated by using the Wilcoxon test.