Features of adherent and nonadherent procoagulant platelets
| Adherent platelets . | Suspended platelets . |
|---|---|
| • PS exposing | • PS exposing |
| • FXa/ FVa binding | • FXa/FVa binding |
| • Thrombin generation | • Thrombin generation |
| • ↑ Membrane permeability | • ↑ Membrane permeability |
| • Loss of Δψm | • Loss of Δψm |
| • Mitochondrial depolarization | • Mitochondrial depolarization |
| • Cyclophilin D dependence | • Cyclophilin D dependence |
| • Microvesiculation | • Microvesiculation |
| • Ballooning | • Ballooning |
| • Procoagulant-spreading |
| Adherent platelets . | Suspended platelets . |
|---|---|
| • PS exposing | • PS exposing |
| • FXa/ FVa binding | • FXa/FVa binding |
| • Thrombin generation | • Thrombin generation |
| • ↑ Membrane permeability | • ↑ Membrane permeability |
| • Loss of Δψm | • Loss of Δψm |
| • Mitochondrial depolarization | • Mitochondrial depolarization |
| • Cyclophilin D dependence | • Cyclophilin D dependence |
| • Microvesiculation | • Microvesiculation |
| • Ballooning | • Ballooning |
| • Procoagulant-spreading |
Procoagulant platelets show similar features, in the presence of physiological concentrations of extracellular calcium, whether studied adherent to a collagen matrix or stimulated with collagen in suspension. A distinguishing feature, unique to adherent platelets, is the formation of procoagulant-spread structures. There are currently no identified features that suspended procoagulant platelets show that are unique to this mode of activation.