Table 1.

PFS of CLL patients receiving frontline chemoimmunotherapy

GroupPFS, moHazard ratios
Median95% CIHR95% CI
FCR 59.10 55.50-64.90 Reference Reference 
Controls (non-FCR regimen) 38.15 34.07-41.65 1.65 1.42-1.91 
 BR 38.41 33.96-44.82 1.57 1.27-1.94 
 FC 35.32 31.14-41.01 1.70 1.40-2.05 
 FCCam Not evaluable* Not evaluable 1.88 0.76-4.66 
 PCR Not evaluable† Not evaluable 1.46 0.88-2.43 
Classified by regimen and IGHV mutation status     
 FCR IGHVmutated Not reached Not evaluable Reference Reference 
 FCR IGHVunmutated 42.88 38.02-51.85 2.89 2.16-3.87 
 BR IGHVmutated 55.37 Not evaluable 1.70 1.06-2.71 
 BR IGHVunmutated 33.60 29.49-38.33 4.10 2.95-5.61 
 FC IGHVmutated 45.17 37.84-56.89 2.54 1.81-3.57 
 FC IGHVunmutated 30.63 25.41-33.66 4.30 3.18-5.81 
Classified by IGHV mutation status     
 FCR IGHVmutated Not reached Not evaluable Reference Reference 
 FCR IGHVunmutated 42.88 38.02-51.85 2.91 2.17-3.89 
 Control IGHVmutated 52.02 43.12-63.75 2.25 1.64-3.10 
 Control IGHVunmutated 32.40 29.26-34.61 4.23 3.19-5.61 
GroupPFS, moHazard ratios
Median95% CIHR95% CI
FCR 59.10 55.50-64.90 Reference Reference 
Controls (non-FCR regimen) 38.15 34.07-41.65 1.65 1.42-1.91 
 BR 38.41 33.96-44.82 1.57 1.27-1.94 
 FC 35.32 31.14-41.01 1.70 1.40-2.05 
 FCCam Not evaluable* Not evaluable 1.88 0.76-4.66 
 PCR Not evaluable† Not evaluable 1.46 0.88-2.43 
Classified by regimen and IGHV mutation status     
 FCR IGHVmutated Not reached Not evaluable Reference Reference 
 FCR IGHVunmutated 42.88 38.02-51.85 2.89 2.16-3.87 
 BR IGHVmutated 55.37 Not evaluable 1.70 1.06-2.71 
 BR IGHVunmutated 33.60 29.49-38.33 4.10 2.95-5.61 
 FC IGHVmutated 45.17 37.84-56.89 2.54 1.81-3.57 
 FC IGHVunmutated 30.63 25.41-33.66 4.30 3.18-5.81 
Classified by IGHV mutation status     
 FCR IGHVmutated Not reached Not evaluable Reference Reference 
 FCR IGHVunmutated 42.88 38.02-51.85 2.91 2.17-3.89 
 Control IGHVmutated 52.02 43.12-63.75 2.25 1.64-3.10 
 Control IGHVunmutated 32.40 29.26-34.61 4.23 3.19-5.61 
*

Mean PFS for FCCam was 20.96 (95% CI, 19.76-22.15).

†

Mean PFS for PCR was 23.91 (95% CI, 21.76-26.05).

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