Associations between SCD-related vascular complications and hemoglobin (quartile 1 vs quartiles 2 to 4 of hemoglobin) in the overall sample, SS-Sβ0, SC, and Sβ+patients: multivariate analysis
| . | . | % of patients with the complication depending on Hb level . | Multivariate analysis* . | |||
|---|---|---|---|---|---|---|
| . | N event/N total . | Quartile 1 . | Quartiles 2 to 4 . | OR . | CI 95% . | P* . |
| Overall sample | ||||||
| TRV >2.5 m/s† | 115/431 | 38.0 | 24.1 | 1.86 | 1.04-3.32 | .035 |
| TRV >3 m/s | 9/431 | 6.5 | 1.0 | 8.94 | 1.54-51.93 | .015 |
| Urine ACR >30 mg/g‡ | 724/1991 | 51.5 | 30.8 | 1.74 | 1.34-2.24 | <.001 |
| Leg ulcer, lifetime | 190/2409 | 9.8 | 7.4 | 1.17 | 0.81-1.71 | .406 |
| Priapism, lifetime§ | 160/1095 | 16.6 | 13.6 | 1.51 | 0.99-2.32 | .057 |
| Stroke, lifetime | 25/2409 | 1.1 | 1.1 | 0.65 | 0.25-1.72 | .387 |
| Osteonecrosis, lifetime | 277/2409 | 10.5 | 11.6 | 0.84 | 0.60-1.19 | .334 |
| SS-Sβ0phenotype | ||||||
| TRV >2.5 m/s† | 95/335 | 41.9 | 24.9 | 2.26 | 1.22-4.17 | .009 |
| TRV >3 m/s | 8/335 | 6.8 | 1.3 | 6.66 | 1.30-34.16 | .023 |
| Urine ACR >30 mg/g‡ | 573/1351 | 52.8 | 38.9 | 1.48 | 1.12-1.95 | .006 |
| Leg ulcer, lifetime | 166/1751 | 10.8 | 9.2 | 1.20 | 0.80-1.78 | .373 |
| Priapism, lifetime§ | 126/809 | 14.8 | 15.4 | 1.11 | 0.69-1.79 | .664 |
| Stroke, lifetime | 23/1751 | 1.2 | 1.4 | 0.66 | 0.24-1.83 | .425 |
| Osteonecrosis, lifetime | 209/1751 | 12.2 | 11.5 | 1.01 | 0.70-1.46 | .948 |
| SC phenotype | ||||||
| TRV >2.5 m/s† | 16/80 | 30.8 | 18.3 | 2.32 | 0.55-9.76 | .005 |
| TRV >3 m/s | 1/80 | 0.0 | 1.7 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 93/339 | 28.9 | 18.6 | 1.85 | 1.06-3.22 | .030 |
| Leg ulcer, lifetime | 18/495 | 4.6 | 3.2 | 1.79 | 0.59-5.42 | .299 |
| Priapism, lifetime§ | 30/218 | 7.1 | 15.4 | 0.46 | 0.13-1.71 | .246 |
| Stroke, lifetime | 2/495 | 0.0 | 0.5 | NA | NA | NA |
| Osteonecrosis, lifetime | 49/495 | 7.3 | 10.6 | 0.84 | 0.37-1.93 | .686 |
| Sβ+ phenotype | ||||||
| TRV >2.5 m/s | 4/16 | 40.0 | 20.0 | 3.97 | 0.17-94.93 | .353 |
| TRV >3 m/s | 0/16 | 0.0 | 0.0 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 26/153 | 28.9 | 13.3 | 1.27 | 0.37-4.33 | .689 |
| Leg ulcer, lifetime | 6/161 | 7.9 | 2.5 | 1.58 | 0.14-17.86 | .711 |
| Priapism, lifetime§ | 4/67 | 5.3 | 1.7 | 0.77 | 0.02-32.13 | .891 |
| Stroke, lifetime | 0/161 | 0.0 | 0.0 | NA | NA | NA |
| Osteonecrosis, lifetime | 19/161 | 10.5 | 12.4 | 0.77 | 0.13-4.75 | .782 |
| . | . | % of patients with the complication depending on Hb level . | Multivariate analysis* . | |||
|---|---|---|---|---|---|---|
| . | N event/N total . | Quartile 1 . | Quartiles 2 to 4 . | OR . | CI 95% . | P* . |
| Overall sample | ||||||
| TRV >2.5 m/s† | 115/431 | 38.0 | 24.1 | 1.86 | 1.04-3.32 | .035 |
| TRV >3 m/s | 9/431 | 6.5 | 1.0 | 8.94 | 1.54-51.93 | .015 |
| Urine ACR >30 mg/g‡ | 724/1991 | 51.5 | 30.8 | 1.74 | 1.34-2.24 | <.001 |
| Leg ulcer, lifetime | 190/2409 | 9.8 | 7.4 | 1.17 | 0.81-1.71 | .406 |
| Priapism, lifetime§ | 160/1095 | 16.6 | 13.6 | 1.51 | 0.99-2.32 | .057 |
| Stroke, lifetime | 25/2409 | 1.1 | 1.1 | 0.65 | 0.25-1.72 | .387 |
| Osteonecrosis, lifetime | 277/2409 | 10.5 | 11.6 | 0.84 | 0.60-1.19 | .334 |
| SS-Sβ0phenotype | ||||||
| TRV >2.5 m/s† | 95/335 | 41.9 | 24.9 | 2.26 | 1.22-4.17 | .009 |
| TRV >3 m/s | 8/335 | 6.8 | 1.3 | 6.66 | 1.30-34.16 | .023 |
| Urine ACR >30 mg/g‡ | 573/1351 | 52.8 | 38.9 | 1.48 | 1.12-1.95 | .006 |
| Leg ulcer, lifetime | 166/1751 | 10.8 | 9.2 | 1.20 | 0.80-1.78 | .373 |
| Priapism, lifetime§ | 126/809 | 14.8 | 15.4 | 1.11 | 0.69-1.79 | .664 |
| Stroke, lifetime | 23/1751 | 1.2 | 1.4 | 0.66 | 0.24-1.83 | .425 |
| Osteonecrosis, lifetime | 209/1751 | 12.2 | 11.5 | 1.01 | 0.70-1.46 | .948 |
| SC phenotype | ||||||
| TRV >2.5 m/s† | 16/80 | 30.8 | 18.3 | 2.32 | 0.55-9.76 | .005 |
| TRV >3 m/s | 1/80 | 0.0 | 1.7 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 93/339 | 28.9 | 18.6 | 1.85 | 1.06-3.22 | .030 |
| Leg ulcer, lifetime | 18/495 | 4.6 | 3.2 | 1.79 | 0.59-5.42 | .299 |
| Priapism, lifetime§ | 30/218 | 7.1 | 15.4 | 0.46 | 0.13-1.71 | .246 |
| Stroke, lifetime | 2/495 | 0.0 | 0.5 | NA | NA | NA |
| Osteonecrosis, lifetime | 49/495 | 7.3 | 10.6 | 0.84 | 0.37-1.93 | .686 |
| Sβ+ phenotype | ||||||
| TRV >2.5 m/s | 4/16 | 40.0 | 20.0 | 3.97 | 0.17-94.93 | .353 |
| TRV >3 m/s | 0/16 | 0.0 | 0.0 | NA | NA | NA |
| Urine ACR >30 mg/g‡ | 26/153 | 28.9 | 13.3 | 1.27 | 0.37-4.33 | .689 |
| Leg ulcer, lifetime | 6/161 | 7.9 | 2.5 | 1.58 | 0.14-17.86 | .711 |
| Priapism, lifetime§ | 4/67 | 5.3 | 1.7 | 0.77 | 0.02-32.13 | .891 |
| Stroke, lifetime | 0/161 | 0.0 | 0.0 | NA | NA | NA |
| Osteonecrosis, lifetime | 19/161 | 10.5 | 12.4 | 0.77 | 0.13-4.75 | .782 |