Table 1. Summary of association results... | American Society of Hematology

Table 1.

Summary of association results in discovery GWAS and replication cohorts

dbSNP locus	Alleles*	Stage	OR (95% CI)†	P
SMAD6 rs12438941	(A) vs G	Discovery GWAS	12.57 (3.00-52.65)	7.99 × 10⁻⁷
		Replication cohort	3.39 (2.29-5.03)	1.30 × 10⁻⁹
		Pooled estimate	3.72 (2.54-5.44)‡	1.29 × 10⁻¹¹

dbSNP locus	Alleles*	Stage	OR (95% CI)†	P
SMAD6 rs12438941	(A) vs G	Discovery GWAS	12.57 (3.00-52.65)	7.99 × 10⁻⁷
		Replication cohort	3.39 (2.29-5.03)	1.30 × 10⁻⁹
		Pooled estimate	3.72 (2.54-5.44)‡	1.29 × 10⁻¹¹

Risk allele in parentheses.

Estimated under an additive genetic model.

Tested under a fixed-effect model.