Patient characteristics for the primary study population (N = 272)
| N (%) or median (IQR) . | France (N = 168) . | The Netherlands (N = 104) . |
|---|---|---|
| Age at last follow-up in years | 32 (27-40) | 28 (21-38) |
| Female sex | 91 (54) | 62 (60) |
| Hemoglobin genotype | ||
| HbSS/HbSβ0 | 163 (97) | 91 (88) |
| HbSC/HbSβ+ | 5 (3) | 13 (12) |
| Ethnicity* | ||
| Africa | 143 (85) | 26 (25) |
| Latin America | 18 (11) | 71 (68) |
| Asia | 0 (0) | 3 (3) |
| Other | 2 (1) | 4 (4) |
| Cumulative transfusion exposure, units | 72 (13-179) | 27 (9-77) |
| N (%) or median (IQR) . | France (N = 168) . | The Netherlands (N = 104) . |
|---|---|---|
| Age at last follow-up in years | 32 (27-40) | 28 (21-38) |
| Female sex | 91 (54) | 62 (60) |
| Hemoglobin genotype | ||
| HbSS/HbSβ0 | 163 (97) | 91 (88) |
| HbSC/HbSβ+ | 5 (3) | 13 (12) |
| Ethnicity* | ||
| Africa | 143 (85) | 26 (25) |
| Latin America | 18 (11) | 71 (68) |
| Asia | 0 (0) | 3 (3) |
| Other | 2 (1) | 4 (4) |
| Cumulative transfusion exposure, units | 72 (13-179) | 27 (9-77) |
Ethnicity was unknown in 5 patients in the French cohort (N = 163).