Overall survival by patient subgroup
| . | Pooled (N = 636) . | |||
|---|---|---|---|---|
| . | Median OS, mo (95% CI) . | 1-y OS rate, % (95% CI) . | 2-y OS rate, % (95% CI) . | Hazard ratio* (P) . |
| Age | ||||
| <65 y | 6.3 (5.8-7.0) | 28 (24-32) | 20 (16-23) | 1 (reference) |
| ≥65 y | 6.9 (4.9-9.5) | 30 (20-40) | 19 (11-29) | 0.9 (.37) |
| ECOG PS | ||||
| 0-1 | 6.5 (6.0-7.6) | 27 (22-33) | 21 (16-26) | 1 (reference) |
| 2+ | 3.0 (2.0-4.3) | 15 (7-24) | 6 (2-14) | 2.1 (<.0001) |
| Disease stage | ||||
| I-II | 8.7 (6.5-11.3) | 39 (29-49) | 31 (22-40) | 1 (reference) |
| III-IV | 5.4 (4.3-6.2) | 20 (15-26) | 15 (10-20) | 1.8 (<.0001) |
| IPI risk classification† | ||||
| Low risk | 9.6 (7.4-16.6) | 44 (34-54) | 35 (26-45) | 1 (reference) |
| Low-intermediate risk | 6.3 (5.2-8.2) | 22 (13-31) | 15 (8-24) | 1.8 (<.0001) |
| High-intermediate to high risk | 3.8 (2.9-5.0) | 15 (9-23) | 10 (5-18) | 2.8 (<.01) |
| . | Pooled (N = 636) . | |||
|---|---|---|---|---|
| . | Median OS, mo (95% CI) . | 1-y OS rate, % (95% CI) . | 2-y OS rate, % (95% CI) . | Hazard ratio* (P) . |
| Age | ||||
| <65 y | 6.3 (5.8-7.0) | 28 (24-32) | 20 (16-23) | 1 (reference) |
| ≥65 y | 6.9 (4.9-9.5) | 30 (20-40) | 19 (11-29) | 0.9 (.37) |
| ECOG PS | ||||
| 0-1 | 6.5 (6.0-7.6) | 27 (22-33) | 21 (16-26) | 1 (reference) |
| 2+ | 3.0 (2.0-4.3) | 15 (7-24) | 6 (2-14) | 2.1 (<.0001) |
| Disease stage | ||||
| I-II | 8.7 (6.5-11.3) | 39 (29-49) | 31 (22-40) | 1 (reference) |
| III-IV | 5.4 (4.3-6.2) | 20 (15-26) | 15 (10-20) | 1.8 (<.0001) |
| IPI risk classification† | ||||
| Low risk | 9.6 (7.4-16.6) | 44 (34-54) | 35 (26-45) | 1 (reference) |
| Low-intermediate risk | 6.3 (5.2-8.2) | 22 (13-31) | 15 (8-24) | 1.8 (<.0001) |
| High-intermediate to high risk | 3.8 (2.9-5.0) | 15 (9-23) | 10 (5-18) | 2.8 (<.01) |