Table 2. Rate of response to... | American Society of Hematology

Table 2.

Rate of response to chemotherapy after refractory disease

	MDACC (n = 165)	IA/MC (n = 82)	LY.12 (CCTG) (n = 219)	CORAL (LYSARC) (n = 170)	Pooled* (N = 636)
Patients evaluated for response, n†	165	82	106	170	523
Response rate, % (95% CI)	20	26	26	31	26 (21-31)
CR rate	7	7	2	15	7 (3-15)
PR rate	13	18	25	16	18 (13-23)
Response rate by refractory category, % (95% CI)
Primary refractory
RR	—	25	27	10	20 (11-34)
CR rate	—	10	1	2	3 (1-11)
Refractory to second-line or later-line therapy
RR	20	21	20	40	26 (17-39)
CR rate	7	5	20	18	10 (5-20)
Relapse ≤12 mo post-ASCT
RR	19	35	—	39	34 (24-45)
CR rate	6	10	—	25	15 (6-31)

	MDACC (n = 165)	IA/MC (n = 82)	LY.12 (CCTG) (n = 219)	CORAL (LYSARC) (n = 170)	Pooled* (N = 636)
Patients evaluated for response, n†	165	82	106	170	523
Response rate, % (95% CI)	20	26	26	31	26 (21-31)
CR rate	7	7	2	15	7 (3-15)
PR rate	13	18	25	16	18 (13-23)
Response rate by refractory category, % (95% CI)
Primary refractory
RR	—	25	27	10	20 (11-34)
CR rate	—	10	1	2	3 (1-11)
Refractory to second-line or later-line therapy
RR	20	21	20	40	26 (17-39)
CR rate	7	5	20	18	10 (5-20)
Relapse ≤12 mo post-ASCT
RR	19	35	—	39	34 (24-45)
CR rate	6	10	—	25	15 (6-31)

Response rate to the line of therapy was given after determination of refractory status.

CI, confidence interval; RR, response rate.

Higgin’s Q statistic, P = .18.

Data contain evidence that the patient proceeded to salvage therapy, but response information was not collected.