Principal associated diseases with LGL leukemia
| Associated diseases with LGL leukemia* . | Frequency (%) . |
|---|---|
| Neoplasms | 4-10 |
| Autoimmune cytopenia | 5 |
| PRCA | |
| AIHA | |
| ITP | |
| Evans syndrome | |
| B-cell lymphoid neoplasms | 5 |
| Low-grade NHL | |
| DLBCL | |
| Mantle cell lymphoma | |
| MM | |
| CLL | |
| Hairy cell leukemia | |
| Waldenstrom macroglobulinemia | |
| Hodgkin lymphoma | |
| Lymphomatoid granulomatosis | |
| Heavy chain disease | |
| Autoimmune diseases/connective tissue disorders | 10-20 |
| RA | 10-18 |
| Systemic lupus erythematosus | |
| Vasculitis | |
| Systemic sclerosis | |
| Endocrinopathy | |
| APECED | |
| MEN-1 | |
| Hashimoto disease | |
| Grave disease | |
| CIBD | |
| Celiac disease | |
| Gougerot-Sjogren syndrome | |
| Glomurolenephritis | |
| Polymyositis | |
| Inclusion body myositis | |
| Poly/multinevritis | |
| RPA | |
| Inflammatory arthritis (unclassified) | |
| Lambert-Eaton myasthenic syndrome | |
| Good syndrome | |
| Behcet disease | |
| MS | |
| Acquired factor VIII inhibitor | |
| MDS | 3-10 |
| AML | <1 |
| Hemophagocytic syndrome | <1 |
| Pulmonary hypertension | <1 |
| Post-organ or hematopoietic SCT | <1 |
| Post viral infection | <1 |
| Associated diseases with LGL leukemia* . | Frequency (%) . |
|---|---|
| Neoplasms | 4-10 |
| Autoimmune cytopenia | 5 |
| PRCA | |
| AIHA | |
| ITP | |
| Evans syndrome | |
| B-cell lymphoid neoplasms | 5 |
| Low-grade NHL | |
| DLBCL | |
| Mantle cell lymphoma | |
| MM | |
| CLL | |
| Hairy cell leukemia | |
| Waldenstrom macroglobulinemia | |
| Hodgkin lymphoma | |
| Lymphomatoid granulomatosis | |
| Heavy chain disease | |
| Autoimmune diseases/connective tissue disorders | 10-20 |
| RA | 10-18 |
| Systemic lupus erythematosus | |
| Vasculitis | |
| Systemic sclerosis | |
| Endocrinopathy | |
| APECED | |
| MEN-1 | |
| Hashimoto disease | |
| Grave disease | |
| CIBD | |
| Celiac disease | |
| Gougerot-Sjogren syndrome | |
| Glomurolenephritis | |
| Polymyositis | |
| Inclusion body myositis | |
| Poly/multinevritis | |
| RPA | |
| Inflammatory arthritis (unclassified) | |
| Lambert-Eaton myasthenic syndrome | |
| Good syndrome | |
| Behcet disease | |
| MS | |
| Acquired factor VIII inhibitor | |
| MDS | 3-10 |
| AML | <1 |
| Hemophagocytic syndrome | <1 |
| Pulmonary hypertension | <1 |
| Post-organ or hematopoietic SCT | <1 |
| Post viral infection | <1 |
AIHA, autoimmune hemolytic anemia; AML, acute myeloid leukemia; APECED, polyendocrinopathy candidosis-ectodermal dystrophy; CIBD, chronic inflammatory bowel disease; CLL, chronic lymphocytic leukemia; DLBCL, diffuse large B-cell lymphoma; ITP, idiopathic thrombocytopenic purpura; MEN-type 1, multiple endocrine neoplasia type 1; MM, multiple myeloma; MS, multiple sclerosis; NHL, non-Hodgkin lymphoma; RPA, rhizomelic pseudopolyarthritis; SCT, stem cell transplantation.
Some patients presented with more than one auto-immune–associated disease.