Classification of LGL leukemia according to the WHO classification
| WHO (2001) . | WHO (2008) . | WHO (2016) . |
|---|---|---|
| Mature T- and NK-cell neoplasms . | Mature T- and NK-cell neoplasms . | Mature T- and NK-cell neoplasms . |
| T-cell LGL leukemia | T-cell LGL leukemia | T-cell granular lymphocytic leukemia |
| Aggressive NK-cell leukemia | Chronic lymphoproliferative disorder of NK cells* | Aggressive NK-cell leukemia |
| Aggressive NK-cell leukemia | Chronic lymphoproliferative disorder of NK cells* | |
| Modifications: | ||
| New subtypes recognized with clinicopathological manifestations | ||
| Stat3 and Stat5b mutations in a subset; latter associated with more clinically aggressive disease |
| WHO (2001) . | WHO (2008) . | WHO (2016) . |
|---|---|---|
| Mature T- and NK-cell neoplasms . | Mature T- and NK-cell neoplasms . | Mature T- and NK-cell neoplasms . |
| T-cell LGL leukemia | T-cell LGL leukemia | T-cell granular lymphocytic leukemia |
| Aggressive NK-cell leukemia | Chronic lymphoproliferative disorder of NK cells* | Aggressive NK-cell leukemia |
| Aggressive NK-cell leukemia | Chronic lymphoproliferative disorder of NK cells* | |
| Modifications: | ||
| New subtypes recognized with clinicopathological manifestations | ||
| Stat3 and Stat5b mutations in a subset; latter associated with more clinically aggressive disease |
Provisional entity.