Demographic and clinical baseline characteristics of study participants (n=10 193)
| Variable . | Total (n = 10 193) . | Categories of factor XI deficiency . | P . | ||
|---|---|---|---|---|---|
| Moderate–severe [≤30%] (n = 542) . | Mild [30%-50%] (n = 693) . | Normal [>50%] (n = 8958) . | |||
| Age, y | 41.0 ± 35.5 | 54.5 ± 21.1 | 47.0 ± 21.0 | 39.7 ± 15.6 | <.001*†‡ |
| Male sex | 2272 (22.3%) | 230 (42.4%) | 293 (42.3%) | 1749 (19.5%) | <.001*† |
| Anticoagulants | 830 (8.1%) | 29 (5.4%) | 50 (7.2%) | 751 (8.4%) | .028* |
| Antiplatelet | 1752 (17.2%) | 121 (22.3%) | 128 (18.5%) | 1503 (16.8%) | .003* |
| Atrial fibrillation | 302 (3.0%) | 44 (8.1%) | 69 (10%) | 189 (2.1%) | <.001*† |
| Malignancy | 762 (7.5%) | 76 (14.0%) | 84 (12.1%) | 602 (6.7%) | <.001*† |
| Diabetes | 651 (6.4%) | 67 (12.4%) | 72 (10.4%) | 512 (5.7%) | <.001*† |
| Cirrhosis | 104 (1.0%) | 23 (4.2%) | 32 (4.6%) | 49 (0.5%) | <.001*† |
| COPD | 179 (1.8%) | 17 (3.1%) | 20 (2.9%) | 142 (1.6%) | .002*† |
| Hypertension | 1642 (16.1%) | 199 (36.7%) | 204 (29.4%) | 1239 (13.8%) | <.001*†‡ |
| IHD | 238 (2.3%) | 21 (3.9%) | 32 (4.6%) | 185 (2.1%) | <.001*† |
| Stroke | 495 (4.9%) | 28 (5.2%) | 39 (5.6%) | 428 (4.8%) | .570 |
| CHF | 185 (1.8%) | 25 (4.6%) | 30 (4.3%) | 130 (1.5%) | <.001*† |
| Hyperlipidemia | 3952 (38.8%) | 278 (51.3%) | 271 (39.1%) | 3403 (38.0%) | <.001*‡ |
| Smoking | 2861 (28.1%) | 149 (27.5%) | 202 (29.1%) | 2510 (28.0%) | .779 |
| Variable . | Total (n = 10 193) . | Categories of factor XI deficiency . | P . | ||
|---|---|---|---|---|---|
| Moderate–severe [≤30%] (n = 542) . | Mild [30%-50%] (n = 693) . | Normal [>50%] (n = 8958) . | |||
| Age, y | 41.0 ± 35.5 | 54.5 ± 21.1 | 47.0 ± 21.0 | 39.7 ± 15.6 | <.001*†‡ |
| Male sex | 2272 (22.3%) | 230 (42.4%) | 293 (42.3%) | 1749 (19.5%) | <.001*† |
| Anticoagulants | 830 (8.1%) | 29 (5.4%) | 50 (7.2%) | 751 (8.4%) | .028* |
| Antiplatelet | 1752 (17.2%) | 121 (22.3%) | 128 (18.5%) | 1503 (16.8%) | .003* |
| Atrial fibrillation | 302 (3.0%) | 44 (8.1%) | 69 (10%) | 189 (2.1%) | <.001*† |
| Malignancy | 762 (7.5%) | 76 (14.0%) | 84 (12.1%) | 602 (6.7%) | <.001*† |
| Diabetes | 651 (6.4%) | 67 (12.4%) | 72 (10.4%) | 512 (5.7%) | <.001*† |
| Cirrhosis | 104 (1.0%) | 23 (4.2%) | 32 (4.6%) | 49 (0.5%) | <.001*† |
| COPD | 179 (1.8%) | 17 (3.1%) | 20 (2.9%) | 142 (1.6%) | .002*† |
| Hypertension | 1642 (16.1%) | 199 (36.7%) | 204 (29.4%) | 1239 (13.8%) | <.001*†‡ |
| IHD | 238 (2.3%) | 21 (3.9%) | 32 (4.6%) | 185 (2.1%) | <.001*† |
| Stroke | 495 (4.9%) | 28 (5.2%) | 39 (5.6%) | 428 (4.8%) | .570 |
| CHF | 185 (1.8%) | 25 (4.6%) | 30 (4.3%) | 130 (1.5%) | <.001*† |
| Hyperlipidemia | 3952 (38.8%) | 278 (51.3%) | 271 (39.1%) | 3403 (38.0%) | <.001*‡ |
| Smoking | 2861 (28.1%) | 149 (27.5%) | 202 (29.1%) | 2510 (28.0%) | .779 |