Characteristics of patients with donor-engrafted HSC clones
| Recipient . | Donor source . | Age at HSCT, y . | Donor age, y* . | Donor-engrafted mutation . | Time of detection, mo . | Donor VAF, %† . | VAF at detection, %‡ . | Clonal evolution . | Additional mutation(s) . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MUD | 57 | 40 | DNMT3A T862N | 18 | 5.9 | 4.4 | Yes | ASXL1, TP53 |
| 2 | MRD | 67 | 59 | DNMT3A Q356X | 13 | 1.6 | 4.0 | No | None |
| 3 | MRD | 51 | 53 | DNMT3A R882H | 4 | 2.6 | 2.6 | No | None |
| 4 | MRD | 68 | 66 | DNMT3A S786X | 6 | 1.5 | 3.7 | No | None |
| 5 | MRD | 63 | 62 | DNMT3A R729Q | 30 | 6.4 | 11.1 | No | None |
| Recipient . | Donor source . | Age at HSCT, y . | Donor age, y* . | Donor-engrafted mutation . | Time of detection, mo . | Donor VAF, %† . | VAF at detection, %‡ . | Clonal evolution . | Additional mutation(s) . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | MUD | 57 | 40 | DNMT3A T862N | 18 | 5.9 | 4.4 | Yes | ASXL1, TP53 |
| 2 | MRD | 67 | 59 | DNMT3A Q356X | 13 | 1.6 | 4.0 | No | None |
| 3 | MRD | 51 | 53 | DNMT3A R882H | 4 | 2.6 | 2.6 | No | None |
| 4 | MRD | 68 | 66 | DNMT3A S786X | 6 | 1.5 | 3.7 | No | None |
| 5 | MRD | 63 | 62 | DNMT3A R729Q | 30 | 6.4 | 11.1 | No | None |
HSC, hematopoietic stem cell; MRD, matched related donor; MUD, matched unrelated donor; VAF, variant allele fraction.
Age of donor at time of HSCT.
VAF of the indicated mutation in donor product collected at the time of HSCT.
VAF of the indicated mutation at the time of detection in the recipient blood or bone marrow after HSCT.