Mouse models
| Mouse models . | Phenotype . | Reference . |
|---|---|---|
| JAK2V617F | ||
| Retrovirus | ||
| C57Bl/6 | PV progressing to MF | 114,-116 |
| BALB/c | Severe lethal PV to MF | 115, 116 |
| Transgenic | ||
| Vav huJAK2V617F | ET/PV progressing to MF | 117 |
| H2K muJak2V617F | ET/PV progressing to MF | 118 |
| Inducible JAK2min promoter huJAK2V617F | ||
| Vav Cre | ET | 57 |
| Mx Cre | PV with thrombocytosis | 57 |
| Pf4Cre (MK specific) | No phenotype | 119 |
| Mild ET and a PV after transplantation | 120 | |
| Tie2Cre (HSC and endothelial cell) | ET with neutrophilia progressing to osteopetrosis with bleeding diathesis | 119 |
| Knock-in | ||
| Constitutive muJak2V617F | PV with thrombocytosis progressing to MF | 121 |
| Germ line induction of muJAK2V617F | PV progressing to MF | 55 |
| E2Acre | ||
| Germ line induction of huJAK2V617F (cDNA) | ||
| Stella Cre | ||
| Heterozygous | Mild ET | 122 |
| Homozygous | PV | 122 |
| muJAK2V617F | ||
| Mx Cre | ||
| Heterozygous | ET/PV progressing to MF | 123 |
| Homozygous | Severe PV progressing to MF | 123 |
| EpoR Cre (erythroid specific) | ||
| Heterozygous | Mild erythrocytosis | 124 |
| Homozygous | Erythrocytosis | 124 |
| muJAK2V617F heterozygous | ||
| Vav Cre | ET progressing to PV progressing to MF | 56 |
| Scl Cre | PV progressing to MF | 125 |
| huJAK2V617F (cDNA) heterozygous | Mild ET progressing in PV (10% cases) | 58 |
| Mx Cre | ||
| CALR | ||
| Retrovirus | ||
| CALRdel52 | Mild ET, ET progressing to MF | 50,51 |
| CALRins5 | Mild ET | 51 |
| Transgenic | ||
| H-2Kb promoter | ET | 126 |
| Knock-in | ||
| Constitutive muCALRdel 61 | ET | 60 |
| Inducible humanized CALRdel52 | Caroline Marty, Isabelle Plo, Harini Nivarthi, R.K., W.V., unpublished results | |
| Vav Cre | ET (short-term follow-up) | |
| SCL CreER | ET (short-term follow-up |
| Mouse models . | Phenotype . | Reference . |
|---|---|---|
| JAK2V617F | ||
| Retrovirus | ||
| C57Bl/6 | PV progressing to MF | 114,-116 |
| BALB/c | Severe lethal PV to MF | 115, 116 |
| Transgenic | ||
| Vav huJAK2V617F | ET/PV progressing to MF | 117 |
| H2K muJak2V617F | ET/PV progressing to MF | 118 |
| Inducible JAK2min promoter huJAK2V617F | ||
| Vav Cre | ET | 57 |
| Mx Cre | PV with thrombocytosis | 57 |
| Pf4Cre (MK specific) | No phenotype | 119 |
| Mild ET and a PV after transplantation | 120 | |
| Tie2Cre (HSC and endothelial cell) | ET with neutrophilia progressing to osteopetrosis with bleeding diathesis | 119 |
| Knock-in | ||
| Constitutive muJak2V617F | PV with thrombocytosis progressing to MF | 121 |
| Germ line induction of muJAK2V617F | PV progressing to MF | 55 |
| E2Acre | ||
| Germ line induction of huJAK2V617F (cDNA) | ||
| Stella Cre | ||
| Heterozygous | Mild ET | 122 |
| Homozygous | PV | 122 |
| muJAK2V617F | ||
| Mx Cre | ||
| Heterozygous | ET/PV progressing to MF | 123 |
| Homozygous | Severe PV progressing to MF | 123 |
| EpoR Cre (erythroid specific) | ||
| Heterozygous | Mild erythrocytosis | 124 |
| Homozygous | Erythrocytosis | 124 |
| muJAK2V617F heterozygous | ||
| Vav Cre | ET progressing to PV progressing to MF | 56 |
| Scl Cre | PV progressing to MF | 125 |
| huJAK2V617F (cDNA) heterozygous | Mild ET progressing in PV (10% cases) | 58 |
| Mx Cre | ||
| CALR | ||
| Retrovirus | ||
| CALRdel52 | Mild ET, ET progressing to MF | 50,51 |
| CALRins5 | Mild ET | 51 |
| Transgenic | ||
| H-2Kb promoter | ET | 126 |
| Knock-in | ||
| Constitutive muCALRdel 61 | ET | 60 |
| Inducible humanized CALRdel52 | Caroline Marty, Isabelle Plo, Harini Nivarthi, R.K., W.V., unpublished results | |
| Vav Cre | ET (short-term follow-up) | |
| SCL CreER | ET (short-term follow-up |
cDNA, complementary DNA.