Table 1. Percentage of D835 mutations in... | American Society of Hematology

Table 1.

Percentage of D835 mutations in ITD⁺ and native FLT3 (ITD^–) alleles in complementary DNA from patients who relapse on quizartinib

Patient number	Sequences ITD^+/–	Mutation	No. of ITD^+/– sequences sampled	Observed alternative codon frequency of ITD⁺ or ITD^– alleles (%)
1005-006	ITD⁺	D835Y	261	39.50
	ITD⁺	D835F	261	2.70
	ITD^–	D835Y	564	16.80
1005-007	ITD⁺	D835V	378	47.40
	ITD⁺	D835Y	378	4.00
	ITD^–	D835V	255	24.70
1005-009	ITD⁺	D835Y	445	50.60
	ITD^–	D835Y	10	50.00
1009-003	ITD⁺	D835F	322	10.60
	ITD⁺	D835Y	322	8.70
	ITD⁺	D835V	322	3.40
	ITD^–	D835Y	266	7.50
	ITD^–	D835F	266	3.80
1009-007	ITD⁺	D835Y	235	55.70
	ITD^–	D835Y	393	25.20
1011-006	ITD⁺	D835Y	402	41.00
	ITD^–	D835Y	825	9.20
1011-007	ITD⁺	D835V	436	29.60
	ITD⁺	D835Y	436	3.00
	ITD^–	D835V	64	28.10

Patient number	Sequences ITD^+/–	Mutation	No. of ITD^+/– sequences sampled	Observed alternative codon frequency of ITD⁺ or ITD^– alleles (%)
1005-006	ITD⁺	D835Y	261	39.50
	ITD⁺	D835F	261	2.70
	ITD^–	D835Y	564	16.80
1005-007	ITD⁺	D835V	378	47.40
	ITD⁺	D835Y	378	4.00
	ITD^–	D835V	255	24.70
1005-009	ITD⁺	D835Y	445	50.60
	ITD^–	D835Y	10	50.00
1009-003	ITD⁺	D835F	322	10.60
	ITD⁺	D835Y	322	8.70
	ITD⁺	D835V	322	3.40
	ITD^–	D835Y	266	7.50
	ITD^–	D835F	266	3.80
1009-007	ITD⁺	D835Y	235	55.70
	ITD^–	D835Y	393	25.20
1011-006	ITD⁺	D835Y	402	41.00
	ITD^–	D835Y	825	9.20
1011-007	ITD⁺	D835V	436	29.60
	ITD⁺	D835Y	436	3.00
	ITD^–	D835V	64	28.10