Table 1.

Characteristics of ITGB2 rs2230531 variant carriers

IndividualSexCohortHM diagnosisAge (y)*Relationship to closest HM case
LK0016-104 Male TFHMS Unaffected 62 Offspring of parent with DLBCL and AML, DNA of parent unavailable 
LK0051-159 Female TFHMS DLBCL 58 NA 
LK0600-005 Female TFHMS Unaffected 71 3 affected siblings (2 with MM and 1 with HL) all negative for variant 
LK0800-001 Male TFHMS AML 59 Nonfamilial 
LK0933-001 Male TFHMS HCL 66 Nonfamilial 
LK2042-056 Female TFHMS Unaffected 69 Offspring of parent with NHL, DNA of parent unavailable 
LK2042-290 Female TFHMS ET 52 NA 
DVA 538 Male TPC Unaffected 69 No known family history of HMs 
DVA 655 Male TPC Unaffected 61 No known family history of HMs 
PCT0-166 Male TPC Unaffected 84 No known family history of HMs 
DVA 1519 Male TPC Unaffected 70 No known family history of HMs 
DVA 1527 Male TPC Unaffected 70 No known family history of HMs 
DVA 1737 Male TPC Unaffected 80 No known family history of HMs 
PCT0-010 Male TCC Unaffected 84 No known family history of HMs 
PCC0-011 Male TCC Unaffected 72 No known family history of HMs 
DVA 88 Male TCC Unaffected 80 No known family history of HMs 
DVA 100 Male TCC Unaffected 82 No known family history of HMs 
PCT0-146 Male TCC Unaffected 77 No known family history of HMs 
DVA 394 Male TCC Unaffected 70 No known family history of HMs 
DVA 1005 Male TCC Unaffected 78 No known family history of HMs 
DVA 1022 Male TCC Unaffected 77 No known family history of HMs 
DVA 1025 Male TCC Unaffected 70 No known family history of HMs 
DVA 1029 Male TCC Unaffected 71 No known family history of HMs 
DVA 1059 Male TCC Unaffected 68 No known family history of HMs 
PC46-002 Male TCC Unaffected 93 No known family history of HMs 
PC65-001 Male TCC Unaffected 82 No known family history of HMs 
IndividualSexCohortHM diagnosisAge (y)*Relationship to closest HM case
LK0016-104 Male TFHMS Unaffected 62 Offspring of parent with DLBCL and AML, DNA of parent unavailable 
LK0051-159 Female TFHMS DLBCL 58 NA 
LK0600-005 Female TFHMS Unaffected 71 3 affected siblings (2 with MM and 1 with HL) all negative for variant 
LK0800-001 Male TFHMS AML 59 Nonfamilial 
LK0933-001 Male TFHMS HCL 66 Nonfamilial 
LK2042-056 Female TFHMS Unaffected 69 Offspring of parent with NHL, DNA of parent unavailable 
LK2042-290 Female TFHMS ET 52 NA 
DVA 538 Male TPC Unaffected 69 No known family history of HMs 
DVA 655 Male TPC Unaffected 61 No known family history of HMs 
PCT0-166 Male TPC Unaffected 84 No known family history of HMs 
DVA 1519 Male TPC Unaffected 70 No known family history of HMs 
DVA 1527 Male TPC Unaffected 70 No known family history of HMs 
DVA 1737 Male TPC Unaffected 80 No known family history of HMs 
PCT0-010 Male TCC Unaffected 84 No known family history of HMs 
PCC0-011 Male TCC Unaffected 72 No known family history of HMs 
DVA 88 Male TCC Unaffected 80 No known family history of HMs 
DVA 100 Male TCC Unaffected 82 No known family history of HMs 
PCT0-146 Male TCC Unaffected 77 No known family history of HMs 
DVA 394 Male TCC Unaffected 70 No known family history of HMs 
DVA 1005 Male TCC Unaffected 78 No known family history of HMs 
DVA 1022 Male TCC Unaffected 77 No known family history of HMs 
DVA 1025 Male TCC Unaffected 70 No known family history of HMs 
DVA 1029 Male TCC Unaffected 71 No known family history of HMs 
DVA 1059 Male TCC Unaffected 68 No known family history of HMs 
PC46-002 Male TCC Unaffected 93 No known family history of HMs 
PC65-001 Male TCC Unaffected 82 No known family history of HMs 

AML, acute myeloid leukemia; DLBCL, diffuse large B-cell lymphoma; ET, essential thrombocythemia; HCL, hairy cell leukemia; HL, Hodgkin lymphoma; MM, multiple myeloma; NA, not applicable; NHL, non-Hodgkin lymphoma (519 males); TCC, Tasmanian non-HM cancer cases; TPC, Tasmanian population controls (344 males undiagnosed with HMs according to Tasmanian Cancer Registry records up to December 2014).

*

Age at diagnosis for HM cases, and current age for non-HM samples.

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