Utility of various evaluations in the diagnosis of ITP
| Basic evaluation . | Tests of potential utility . | Tests of unproven benefit . |
|---|---|---|
| Patient/family history | Glycoprotein-specific antibody | Thrombopoietin |
| Physical examination | Antiphospholipid antibodies (including anticardiolipin and lupus anticoagulant) | Reticulated platelets |
| Complete blood count and reticulocyte count | Antithyroid antibodies and thyroid function | Platelet-associated immunoglobulin G |
| Peripheral blood film | Pregnancy test in women of childbearing potential | Bleeding time |
| Quantitative immunoglobulin level measurement* | Antinuclear antibodies | Platelet survival study |
| Bone marrow examination (in selected patients) | Viral PCR for parvovirus and CMV | Serum complement |
| Blood group (Rh) | ||
| Direct antiglobulin test | ||
| H pylori† | ||
| HIV† | ||
| HCV† |
| Basic evaluation . | Tests of potential utility . | Tests of unproven benefit . |
|---|---|---|
| Patient/family history | Glycoprotein-specific antibody | Thrombopoietin |
| Physical examination | Antiphospholipid antibodies (including anticardiolipin and lupus anticoagulant) | Reticulated platelets |
| Complete blood count and reticulocyte count | Antithyroid antibodies and thyroid function | Platelet-associated immunoglobulin G |
| Peripheral blood film | Pregnancy test in women of childbearing potential | Bleeding time |
| Quantitative immunoglobulin level measurement* | Antinuclear antibodies | Platelet survival study |
| Bone marrow examination (in selected patients) | Viral PCR for parvovirus and CMV | Serum complement |
| Blood group (Rh) | ||
| Direct antiglobulin test | ||
| H pylori† | ||
| HIV† | ||
| HCV† |
Adapted from Provan et al.4
CMV, cytomegalovirus; HCV, hepatitis C virus; PCR, polymerase chain reaction; Rh, rhesus.
Quantitative immunoglobulin level measurement should be considered in children with ITP and is recommended in those children with persistent or chronic ITP as part of reassessment evaluation.
Recommended by the majority of the panel for adult patients regardless of geographic location.