Patient characteristics
| . | Initial phase . | % . | Phase 1 . | % . | Phase 2 . | % . | Phase 3 . | % . | Phase 4 . | % . | MRD phase . | % . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number | 69 | 61 | 28 | 78 | 83 | 178 | ||||||
| Age, y | ||||||||||||
| Median | 6 | 5 | 5 | 5 | 3 | 5 | ||||||
| Minimum | 0 | 1 | 1 | 0 | 0 | 0 | ||||||
| Maximum | 76 | 75 | 17 | 17 | 55 | 77 | ||||||
| Sex | ||||||||||||
| Male | 35 | 56 | 40 | 66 | 14 | 50 | 46 | 59 | 43 | 52 | 94 | 53 |
| Female | 27 | 44 | 21 | 34 | 14 | 50 | 32 | 41 | 40 | 48 | 84 | 47 |
| White blood cell count (×109/L) | ||||||||||||
| Median | 13.4 | 8.2 | 13.7 | 10.9 | 15.9 | 8.5 | ||||||
| Minimum | 0.4 | 0.8 | 1.2 | 0.7 | 0.5 | 0.5 | ||||||
| Maximum | 818 | 87.6 | 312 | 595 | 1250 | 900 | ||||||
| No data | 10 | 1 | 0 | 2 | 19 | 11 | ||||||
| Immunophenotype | ||||||||||||
| Pro-B-ALL | 8 | 13 | 2 | 3 | 4 | 14 | 5 | 6 | 6 | 7 | 5 | 3 |
| Common-ALL | 44 | 73 | 48 | 79 | 20 | 71 | 59 | 76 | 56 | 67 | 137 | 77 |
| Pre-B-ALL | 8 | 13 | 11 | 18 | 4 | 14 | 13 | 17 | 21 | 25 | 35 | 20 |
| No data | 7 | 0 | 0 | 1 | 0 | 1 | ||||||
| Genetic data* | ||||||||||||
| TEL-AML1 | 6 | 11 | 15 | 27 | 6 | 27 | 11 | 16 | 11 | 18 | 45 | 26 |
| BCR-ABL | 4 | 6 | 1 | 2 | 0 | 0 | 3 | 4 | 1 | 2 | 4 | 2 |
| E2A-PBX1 | 0 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 |
| MLL-AF4 | 4 | 6 | 1 | 2 | 2 | 7 | 3 | 4 | 4 | 6 | 3 | 2 |
| MLL other | 2 | 3 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 2 | 2 | 1 |
| Hyperdiplod | 14 | 25 | 27 | 48 | 6 | 26 | 26 | 37 | 22 | 37 | 67 | 43 |
| Hypodiploid | 0 | 0 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 2 | 2 | 1 |
| . | Initial phase . | % . | Phase 1 . | % . | Phase 2 . | % . | Phase 3 . | % . | Phase 4 . | % . | MRD phase . | % . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number | 69 | 61 | 28 | 78 | 83 | 178 | ||||||
| Age, y | ||||||||||||
| Median | 6 | 5 | 5 | 5 | 3 | 5 | ||||||
| Minimum | 0 | 1 | 1 | 0 | 0 | 0 | ||||||
| Maximum | 76 | 75 | 17 | 17 | 55 | 77 | ||||||
| Sex | ||||||||||||
| Male | 35 | 56 | 40 | 66 | 14 | 50 | 46 | 59 | 43 | 52 | 94 | 53 |
| Female | 27 | 44 | 21 | 34 | 14 | 50 | 32 | 41 | 40 | 48 | 84 | 47 |
| White blood cell count (×109/L) | ||||||||||||
| Median | 13.4 | 8.2 | 13.7 | 10.9 | 15.9 | 8.5 | ||||||
| Minimum | 0.4 | 0.8 | 1.2 | 0.7 | 0.5 | 0.5 | ||||||
| Maximum | 818 | 87.6 | 312 | 595 | 1250 | 900 | ||||||
| No data | 10 | 1 | 0 | 2 | 19 | 11 | ||||||
| Immunophenotype | ||||||||||||
| Pro-B-ALL | 8 | 13 | 2 | 3 | 4 | 14 | 5 | 6 | 6 | 7 | 5 | 3 |
| Common-ALL | 44 | 73 | 48 | 79 | 20 | 71 | 59 | 76 | 56 | 67 | 137 | 77 |
| Pre-B-ALL | 8 | 13 | 11 | 18 | 4 | 14 | 13 | 17 | 21 | 25 | 35 | 20 |
| No data | 7 | 0 | 0 | 1 | 0 | 1 | ||||||
| Genetic data* | ||||||||||||
| TEL-AML1 | 6 | 11 | 15 | 27 | 6 | 27 | 11 | 16 | 11 | 18 | 45 | 26 |
| BCR-ABL | 4 | 6 | 1 | 2 | 0 | 0 | 3 | 4 | 1 | 2 | 4 | 2 |
| E2A-PBX1 | 0 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 2 |
| MLL-AF4 | 4 | 6 | 1 | 2 | 2 | 7 | 3 | 4 | 4 | 6 | 3 | 2 |
| MLL other | 2 | 3 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 2 | 2 | 1 |
| Hyperdiplod | 14 | 25 | 27 | 48 | 6 | 26 | 26 | 37 | 22 | 37 | 67 | 43 |
| Hypodiploid | 0 | 0 | 1 | 2 | 1 | 4 | 1 | 1 | 1 | 2 | 2 | 1 |
Genetic data were not available for all patients; percentages refer to positive patients per all analyzed patients.