Notable patient characteristics by IGVL gene usage for most abundant clones*
| Gene . | Organ involvement . | dFLC levels/amyloidogenicity . | Organ toxicity . | FISH abnormalities . |
|---|---|---|---|---|
| LV6-57 (n = 102) | ↑ Renal involvement: 79% vs 48%, P = .0004 | No differences | 24-h urine protein >5 g 56% vs 34%, P = .02† | ↑t(11;14) 55% vs 40%, P < .05↓Trisomies 9.5% vs 22%, P < .05 |
| LV3-01 (n = 66) | ↓ Renal involvement: 41% vs 54%, P < .05 | No differences | ↓ Mayo stage III, 26% vs 43%, P = .02† | No differences |
| LV2-14 (n = 64) | ↑ In gastrointestinal ALL | ↓ dFLC 9.47 vs 24.5 mg/dL, P = .025 | No differences | No differences |
| ↑ Peripheral nerve involvement: 25% vs 14%, P < .05 | ↑ Intact circulating Ig 80% vs 57%, P = .002 | |||
| LV1-44 (n = 45) | ↑ Cardiac involvement: 80% vs 65%, P = .03 | No differences | No differences | ↓Trisomies 4% vs 22%, P < .05 |
| KV1-33 (n = 40) | ↑ Liver involvement 27% vs 7%, P = .0002 | ↑ dFLC 64.8 mg/dL vs 22.2 mg/dL, P < .002 | No differences | No differences |
| ↓ Peripheral nerve involvement 2.7% vs 15.6%, P = .017 | ||||
| LV3-21 (n = 38) | ↓ Renal involvement 29% vs 54%, P = .0025 | No differences | ↑ Monosomy 13q/13q 61% vs 33%, P = .017 |
| Gene . | Organ involvement . | dFLC levels/amyloidogenicity . | Organ toxicity . | FISH abnormalities . |
|---|---|---|---|---|
| LV6-57 (n = 102) | ↑ Renal involvement: 79% vs 48%, P = .0004 | No differences | 24-h urine protein >5 g 56% vs 34%, P = .02† | ↑t(11;14) 55% vs 40%, P < .05↓Trisomies 9.5% vs 22%, P < .05 |
| LV3-01 (n = 66) | ↓ Renal involvement: 41% vs 54%, P < .05 | No differences | ↓ Mayo stage III, 26% vs 43%, P = .02† | No differences |
| LV2-14 (n = 64) | ↑ In gastrointestinal ALL | ↓ dFLC 9.47 vs 24.5 mg/dL, P = .025 | No differences | No differences |
| ↑ Peripheral nerve involvement: 25% vs 14%, P < .05 | ↑ Intact circulating Ig 80% vs 57%, P = .002 | |||
| LV1-44 (n = 45) | ↑ Cardiac involvement: 80% vs 65%, P = .03 | No differences | No differences | ↓Trisomies 4% vs 22%, P < .05 |
| KV1-33 (n = 40) | ↑ Liver involvement 27% vs 7%, P = .0002 | ↑ dFLC 64.8 mg/dL vs 22.2 mg/dL, P < .002 | No differences | No differences |
| ↓ Peripheral nerve involvement 2.7% vs 15.6%, P = .017 | ||||
| LV3-21 (n = 38) | ↓ Renal involvement 29% vs 54%, P = .0025 | No differences | ↑ Monosomy 13q/13q 61% vs 33%, P = .017 |
BMPC, bone marrow plasma cells.
Characteristics tested for significance included: dFLC, circulating intact immunoglobulin, bone marrow plasma cells, presence of t(11;14), deletion 13q or trisomies by FISH, renal involvement, cardiac involvement, nerve involvement, liver involvement, Mayo 2004 cardiac stage, urine total protein, and estimated glomerular filtration rate.
Comparison group for each row is patients not harboring this IGVL gene.
Independent of baseline dFLC levels.