Mutation profile of study patients
| Variables . | Pre-PMF, N = 278 . | Overt PMF, N = 383 . | P . |
|---|---|---|---|
| Driver mutation, n (%) | |||
| JAK2V617F | 187 (67.2) | 223 (58.2) | .091 |
| CALR | |||
| Type 1 | 34 (12.2) | 68 (17.8) | |
| Type 2 | 16 (5.8) | 17 (4.4) | |
| MPLW515x | 13 (4.7) | 23 (6.0) | |
| TN | 28 (10.1) | 52 (13.6) | |
| Allele burden, mean ± SD, % | |||
| JAK2V617F | 44.5 ± 20.9 | 47.8 ± 20.9 | .50 |
| MPLW515x | 48.9 ± 34.7 | 55.4 ± 22.6 | .60 |
| CALR | 47.8 ± 13.2 | 53.3 ± 10.3 | .16 |
| Mutated, n (%) | |||
| ASXL1 | 50 (18.0) | 129 (33.7) | <.0001 |
| EZH2 | 10 (3.6) | 46 (12.0) | <.0001 |
| SRSF2 | 25 (9.0) | 41 (10.7) | .28 |
| IDH1/2 | 6 (2.2) | 13 (3.4) | .24 |
| HMR, n (%) | |||
| =1 | 75 (27.0) | 170 (44.4) | <.0001 |
| ≥2 | 15 (5.4) | 52 (13.6) | <.0001 |
| Variables . | Pre-PMF, N = 278 . | Overt PMF, N = 383 . | P . |
|---|---|---|---|
| Driver mutation, n (%) | |||
| JAK2V617F | 187 (67.2) | 223 (58.2) | .091 |
| CALR | |||
| Type 1 | 34 (12.2) | 68 (17.8) | |
| Type 2 | 16 (5.8) | 17 (4.4) | |
| MPLW515x | 13 (4.7) | 23 (6.0) | |
| TN | 28 (10.1) | 52 (13.6) | |
| Allele burden, mean ± SD, % | |||
| JAK2V617F | 44.5 ± 20.9 | 47.8 ± 20.9 | .50 |
| MPLW515x | 48.9 ± 34.7 | 55.4 ± 22.6 | .60 |
| CALR | 47.8 ± 13.2 | 53.3 ± 10.3 | .16 |
| Mutated, n (%) | |||
| ASXL1 | 50 (18.0) | 129 (33.7) | <.0001 |
| EZH2 | 10 (3.6) | 46 (12.0) | <.0001 |
| SRSF2 | 25 (9.0) | 41 (10.7) | .28 |
| IDH1/2 | 6 (2.2) | 13 (3.4) | .24 |
| HMR, n (%) | |||
| =1 | 75 (27.0) | 170 (44.4) | <.0001 |
| ≥2 | 15 (5.4) | 52 (13.6) | <.0001 |
MPLW515x means any mutation occurring at codon 515. HMR =1 points to the presence of at least 1 mutation in any 1 of ASXL1, EZH2, SRSF2, IDH1/2. HMR ≥2 means the presence of 2 or more mutated genes among the above. Two or more mutations in the same gene are counted as 1. For the calculation of CALR allele burden, type 1 and type 2 mutations were considered together.
SD, standard deviation.