Table 1.

Univariate and multivariate analysis for OS and TTFT

VariableUnivariate analysisMultivariate analysis, n = 228
HR (95% CI)PHR (95% CI)PAfter bootstrapping
HR (95% CI)P
OS       
 CLL-IPI       
  Low    
  Intermediate 2.593 (1.121-6.001) .026 2.074 (0.853-5.237) .108 2.074 (0.822-5.049) .122 
  High 4.828 (2.152-10.834) <.001 5.716 (2.434-13.423) <.001 5.716 (2.516-12.989) <.001 
  Very high 13.628 (4.742-39.166) <.001 4.875 (1.399-16.984) .013 4.875 (1.161-20.477) .031 
 CIRS ≤6/>6 3.843 (2.433-6.071) <.001 2.899 (1.521-5.523) .001 2.899 (1.352-6.217) .006 
 CK, yes/no 3.176 (1.882-5.359) <.001 3.572 (1.572-8.116) .002 3.572 (1.341-9.515) .011 
TTFT       
 CLL-IPI       
  Low    
  Intermediate 6.640 (2.993-14.729) <.001 6.214 (2.788-13.853) <.001 6.214 (2.171-17.790) .001 
  High 20.831 (9.588-45.260) <.001 22.308 (10.214-48.720) <.001 22.308 (7.718-64.480) <.001 
  Very high 25.637 (9.748-67.425) <.001 15.811 (5.611-44.555) <.001 15.811 (4.425-56.502) <.001 
 CIRS ≤6/>6 1.151 (0.794-1.669) .407 — — — — 
 CK, yes/no 2.521 (1.606-3.958) <.001 2.157 (1.185-3.926) .012 2.157 (1.177-3.952) .013 
VariableUnivariate analysisMultivariate analysis, n = 228
HR (95% CI)PHR (95% CI)PAfter bootstrapping
HR (95% CI)P
OS       
 CLL-IPI       
  Low    
  Intermediate 2.593 (1.121-6.001) .026 2.074 (0.853-5.237) .108 2.074 (0.822-5.049) .122 
  High 4.828 (2.152-10.834) <.001 5.716 (2.434-13.423) <.001 5.716 (2.516-12.989) <.001 
  Very high 13.628 (4.742-39.166) <.001 4.875 (1.399-16.984) .013 4.875 (1.161-20.477) .031 
 CIRS ≤6/>6 3.843 (2.433-6.071) <.001 2.899 (1.521-5.523) .001 2.899 (1.352-6.217) .006 
 CK, yes/no 3.176 (1.882-5.359) <.001 3.572 (1.572-8.116) .002 3.572 (1.341-9.515) .011 
TTFT       
 CLL-IPI       
  Low    
  Intermediate 6.640 (2.993-14.729) <.001 6.214 (2.788-13.853) <.001 6.214 (2.171-17.790) .001 
  High 20.831 (9.588-45.260) <.001 22.308 (10.214-48.720) <.001 22.308 (7.718-64.480) <.001 
  Very high 25.637 (9.748-67.425) <.001 15.811 (5.611-44.555) <.001 15.811 (4.425-56.502) <.001 
 CIRS ≤6/>6 1.151 (0.794-1.669) .407 — — — — 
 CK, yes/no 2.521 (1.606-3.958) <.001 2.157 (1.185-3.926) .012 2.157 (1.177-3.952) .013 

TTFT was calculated as the interval between diagnosis and the start of first-line treatment. OS was calculated from the date of diagnosis until death due to any cause or until the last patient follow-up. Proportional hazards regression analysis was used to identify the significant independent prognostic variables on TTFT. The stability of the Cox model was internally validated using bootstrapping procedures. Statistical analysis was performed using Stata 14.0 (Stata Corp, College Station, TX).

—, not applicable; CI, confidence interval; HR, hazard ratio.

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