Toxicities observed on BV therapy
| Dose . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| 0.6 mg/kg weekly | Anemia | Anemia | Thrombocytopenia | |
| Neutropenia | Neutropenia | |||
| Nausea | Abdominal pain | |||
| Elevated creatinine | Weakness (2) | |||
| Fatigue | ||||
| 0.9 mg/kg weekly | Edema | Anemia (2) | Neutropenia | Sepsis |
| Thrombocytopenia | Thrombocytopenia | |||
| Nausea | ||||
| 0.6 mg/kg every other week | Anemia | Neutropenia | Thrombocytopenia | |
| Neutropenia | Thrombocytopenia (3) | |||
| Pneumonia | ||||
| 0.8 mg/kg every other week | Neutropenia | Neutropenia | Neutropenia | |
| Thrombocytopenia (2) | Headache | Thrombocytopenia | ||
| Fatigue (2) | Hypoxia | Sepsis | ||
| Abdominal distention (2) | Ileus | |||
| Hypertension | Elevated bilirubin | |||
| Myalgias (2) | ||||
| Arthralgias |
| Dose . | Grade 2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| 0.6 mg/kg weekly | Anemia | Anemia | Thrombocytopenia | |
| Neutropenia | Neutropenia | |||
| Nausea | Abdominal pain | |||
| Elevated creatinine | Weakness (2) | |||
| Fatigue | ||||
| 0.9 mg/kg weekly | Edema | Anemia (2) | Neutropenia | Sepsis |
| Thrombocytopenia | Thrombocytopenia | |||
| Nausea | ||||
| 0.6 mg/kg every other week | Anemia | Neutropenia | Thrombocytopenia | |
| Neutropenia | Thrombocytopenia (3) | |||
| Pneumonia | ||||
| 0.8 mg/kg every other week | Neutropenia | Neutropenia | Neutropenia | |
| Thrombocytopenia (2) | Headache | Thrombocytopenia | ||
| Fatigue (2) | Hypoxia | Sepsis | ||
| Abdominal distention (2) | Ileus | |||
| Hypertension | Elevated bilirubin | |||
| Myalgias (2) | ||||
| Arthralgias |
Numbers in parentheses refer to the number of patients experiencing each toxicity. Grading of toxicities was done by CTCAE v4.0