Summary of case reports of spontaneous HIT
| Patient . | Age . | Sex . | Recent hospitalization (<3 mo) . | Antecedent illness . | Platelet count at presentation . | Thrombosis at presentation . | IgG EIA . | SRA . | Outcome . | Reference . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 69 | M | No | Five-day course of ampicillin for periodontitis and intra-articular injection methylprednisolone 8 d prior | 17 | Bilateral iliac femoral artery thromboses | 2.03 | Positive | Death | 129 |
| 2 | 40 | F | No | I&D of groin cysts | 297→175K (hours)→59K within 24 h of UFH | Right MCA thrombosis/femoral artery thrombosis | 2.91 | Positive | Survived | 129 |
| 3 | 24 | F | No | 2 wk h/o URI; 1 wk h/o pneumonia | 301K→62 after 2 doses LMWH | 2.62 | Positive | Survived | 129 | |
| 4 | 69 | F | No | Right total knee replacement 7 d prior | 205K→124K over 7 d | Cardiac arrest; bilateral adrenal hemorrhage/DIC | 1.89 | Positive | Death | 130 |
| 5 | 62 | M | No | None | 65 × 109/L | Left MCA thrombosis | 1.06 | Positive | Survived | 58 |
| 6 | 54 | F | Yes | Right shoulder hemiarthroplasty 15 d prior | 61 | Left posterior cerebral artery thrombosis and left vertebral artery thrombosis | 2.87 | Positive | Survived | 58 |
| 7 | 61 | F | None | Right total knee replacement 7 d prior | 251K→29 by postoperative day 9 | Right greater saphenous vein thrombosis and nonocclusive left popliteal and femoral DVTs | 2.3 | Positive | Survived | 131 |
| Patient . | Age . | Sex . | Recent hospitalization (<3 mo) . | Antecedent illness . | Platelet count at presentation . | Thrombosis at presentation . | IgG EIA . | SRA . | Outcome . | Reference . |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 69 | M | No | Five-day course of ampicillin for periodontitis and intra-articular injection methylprednisolone 8 d prior | 17 | Bilateral iliac femoral artery thromboses | 2.03 | Positive | Death | 129 |
| 2 | 40 | F | No | I&D of groin cysts | 297→175K (hours)→59K within 24 h of UFH | Right MCA thrombosis/femoral artery thrombosis | 2.91 | Positive | Survived | 129 |
| 3 | 24 | F | No | 2 wk h/o URI; 1 wk h/o pneumonia | 301K→62 after 2 doses LMWH | 2.62 | Positive | Survived | 129 | |
| 4 | 69 | F | No | Right total knee replacement 7 d prior | 205K→124K over 7 d | Cardiac arrest; bilateral adrenal hemorrhage/DIC | 1.89 | Positive | Death | 130 |
| 5 | 62 | M | No | None | 65 × 109/L | Left MCA thrombosis | 1.06 | Positive | Survived | 58 |
| 6 | 54 | F | Yes | Right shoulder hemiarthroplasty 15 d prior | 61 | Left posterior cerebral artery thrombosis and left vertebral artery thrombosis | 2.87 | Positive | Survived | 58 |
| 7 | 61 | F | None | Right total knee replacement 7 d prior | 251K→29 by postoperative day 9 | Right greater saphenous vein thrombosis and nonocclusive left popliteal and femoral DVTs | 2.3 | Positive | Survived | 131 |
DIC, disseminated intravascular coagulation; DVT, deep vein thrombosis; EIA, enzyme immunoassay; F, female; h/o, history of; I&D, incision and drainage; K, thousand; M, male; MCA, middle cerebral artery; RLE, right lower extremity; URI, upper respiratory infection.