Table 1. Sickle cell guidelines and... | American Society of Hematology

Table 1.

Sickle cell guidelines and recommendations with relevance for sub-Saharan Africa

Topic	Goal	Age range	Applicable to Africa	Feasible for Africa	Need for more testing	Current trials
Screening	Diagnosis
Electrophoresis by IEF, HPLC, CZE		Neonates, teens, young adults	Yes	Yes	No	No
Point-of-care testing		Neonates, teens, young adults	Yes	Yes	Yes	Yes
Education	Early recognition
Splenic sequestration		<2 y	Yes	Yes	No	No
Fever management		All ages	Yes	Yes	No	No
Preventive care	Prophylaxis
Antimalarials		All ages	Yes	Yes	Yes	Yes
Insecticide-treated bed nets		All Ages	Yes	Yes	No	No
Penicillin		<5 y	Yes	Yes	No	No
Vaccination		<5 y	Yes	Yes	No	No
Antibiotics for fever		All ages	Yes	Yes	No	No
Blood culture with fever		All ages	Yes	No	No	No
Screening	Early identification
TCD ultrasound		2-16 y	Yes	Yes	Yes	Yes
Proteinuria		All ages	Yes	Yes	Yes	Yes
Cardiac function (TR Jet velocity)		Adults	Possibly	Possibly	Yes	No
Treatment	Therapeutic
Transfusions		All ages	Yes	Yes	Yes	No
Hydroxyurea		All ages	Yes	Yes	Yes	Yes
Transplantation		All ages	No	No	No	No

Topic	Goal	Age range	Applicable to Africa	Feasible for Africa	Need for more testing	Current trials
Screening	Diagnosis
Electrophoresis by IEF, HPLC, CZE		Neonates, teens, young adults	Yes	Yes	No	No
Point-of-care testing		Neonates, teens, young adults	Yes	Yes	Yes	Yes
Education	Early recognition
Splenic sequestration		<2 y	Yes	Yes	No	No
Fever management		All ages	Yes	Yes	No	No
Preventive care	Prophylaxis
Antimalarials		All ages	Yes	Yes	Yes	Yes
Insecticide-treated bed nets		All Ages	Yes	Yes	No	No
Penicillin		<5 y	Yes	Yes	No	No
Vaccination		<5 y	Yes	Yes	No	No
Antibiotics for fever		All ages	Yes	Yes	No	No
Blood culture with fever		All ages	Yes	No	No	No
Screening	Early identification
TCD ultrasound		2-16 y	Yes	Yes	Yes	Yes
Proteinuria		All ages	Yes	Yes	Yes	Yes
Cardiac function (TR Jet velocity)		Adults	Possibly	Possibly	Yes	No
Treatment	Therapeutic
Transfusions		All ages	Yes	Yes	Yes	No
Hydroxyurea		All ages	Yes	Yes	Yes	Yes
Transplantation		All ages	No	No	No	No