Main features in pediatric and adult thrombocytosis
| . | PedET (n = 21) . | PedST (n = 6) . | AdET (n = 36) . |
|---|---|---|---|
| Age, y, median (range) | 10 (1-16) | 7.8 (2-5) | 51.8 (30-80) |
| Sex (male/female) | 14/7 | 2/4 | 10/26 |
| JAK2V617F | 6 | NA | 14 |
| CALR (type 1/2) | 2 (1/1) | NA | 9 (4/5) |
| MPLW515L | 1 | NA | 2 |
| 3NEG | 12 | NA | 11 |
| Cellularity, %, median (range) | 80 (55-95) | 80 (50-80) | 55 (20-80) |
| MKD, MK/mm2, median (range) | 37.5 (10-107) | 9.2 (6-14) | 18.3 (9-55) |
| MKD/BM cellularity, median (range) | 46.6 (13-134) | 15.6 (11-19) | 45.8 (15-105) |
| Presence of MK loose clusters, n (%) | 21 (100) | 0 | 36 (100) |
| Presence of MK dense clusters, n (%) | 3 (14) | 0 | 0 |
| Presence of BM reticulin fibrosis, n (%) | 6 (28.5)* | 0 | 6 (16.7) |
| . | PedET (n = 21) . | PedST (n = 6) . | AdET (n = 36) . |
|---|---|---|---|
| Age, y, median (range) | 10 (1-16) | 7.8 (2-5) | 51.8 (30-80) |
| Sex (male/female) | 14/7 | 2/4 | 10/26 |
| JAK2V617F | 6 | NA | 14 |
| CALR (type 1/2) | 2 (1/1) | NA | 9 (4/5) |
| MPLW515L | 1 | NA | 2 |
| 3NEG | 12 | NA | 11 |
| Cellularity, %, median (range) | 80 (55-95) | 80 (50-80) | 55 (20-80) |
| MKD, MK/mm2, median (range) | 37.5 (10-107) | 9.2 (6-14) | 18.3 (9-55) |
| MKD/BM cellularity, median (range) | 46.6 (13-134) | 15.6 (11-19) | 45.8 (15-105) |
| Presence of MK loose clusters, n (%) | 21 (100) | 0 | 36 (100) |
| Presence of MK dense clusters, n (%) | 3 (14) | 0 | 0 |
| Presence of BM reticulin fibrosis, n (%) | 6 (28.5)* | 0 | 6 (16.7) |
MKD, megakaryocytes density; NA, not available.
Two of these cases had histological features consistent with pre-PMF, 1 had masked PV, and 3 had ET.