Variables stably incorporated in multivariate model for posttransplant survival
| Covariates . | n (%) . | HR (95% CI) . | Coeff. . | P . |
|---|---|---|---|---|
| Genetic factors | ||||
| NRAS mutation | 54 (6.8) | 1.64 (1.14-2.35) | 0.49 | .0075 |
| TP53 mutation | 101 (12.7) | 1.49 (1.10-2.00) | 0.40 | .0096 |
| CBL mutation | 46 (5.8) | 1.55 (1.06-2.26) | 0.44 | .024 |
| CK | 218 (27.4) | 1.45 (1.01-2.09) | 0.37 | .046 |
| High-risk cytogenetic abnormality | 303 (38.1) | 1.29 (0.92-1.82) | 0.26 | .14 |
| Clinical factors | ||||
| Age at HCT, ≥41.5 y | 601 (75.8) | 1.69 (1.29-2.22) | 0.53 | .00014 |
| PS, ≥3 | 63 (8.2) | 1.90 (1.36-2.68) | 0.64 | .00021 |
| HCT-CI, score ≥3 | 143 (18.0) | 1.52 (1.17-1.98) | 0.42 | .0016 |
| RBC transfusion history, negative | 99 (12.7) | 0.52 (0.34-0.81) | −0.65 | .0038 |
| Female donor to male | 139 (17.6) | 1.43 (1.12-1.84) | 0.36 | .0042 |
| Dx at HCT: sAML | 203 (25.6) | 1.32 (1.04-1.68) | 0.28 | .020 |
| Days from Dx to HCT, ≥1275 d | 105 (13.3) | 0.64 (0.44-0.94) | −0.44 | .022 |
| Disease status | ||||
| CR | 106 (13.7) | 0.69 (0.48-0.99) | −0.37 | .044 |
| Ref/Rel | 237 (29.7) | 1.23 (0.97-1.55) | 0.20 | .086 |
| Covariates . | n (%) . | HR (95% CI) . | Coeff. . | P . |
|---|---|---|---|---|
| Genetic factors | ||||
| NRAS mutation | 54 (6.8) | 1.64 (1.14-2.35) | 0.49 | .0075 |
| TP53 mutation | 101 (12.7) | 1.49 (1.10-2.00) | 0.40 | .0096 |
| CBL mutation | 46 (5.8) | 1.55 (1.06-2.26) | 0.44 | .024 |
| CK | 218 (27.4) | 1.45 (1.01-2.09) | 0.37 | .046 |
| High-risk cytogenetic abnormality | 303 (38.1) | 1.29 (0.92-1.82) | 0.26 | .14 |
| Clinical factors | ||||
| Age at HCT, ≥41.5 y | 601 (75.8) | 1.69 (1.29-2.22) | 0.53 | .00014 |
| PS, ≥3 | 63 (8.2) | 1.90 (1.36-2.68) | 0.64 | .00021 |
| HCT-CI, score ≥3 | 143 (18.0) | 1.52 (1.17-1.98) | 0.42 | .0016 |
| RBC transfusion history, negative | 99 (12.7) | 0.52 (0.34-0.81) | −0.65 | .0038 |
| Female donor to male | 139 (17.6) | 1.43 (1.12-1.84) | 0.36 | .0042 |
| Dx at HCT: sAML | 203 (25.6) | 1.32 (1.04-1.68) | 0.28 | .020 |
| Days from Dx to HCT, ≥1275 d | 105 (13.3) | 0.64 (0.44-0.94) | −0.44 | .022 |
| Disease status | ||||
| CR | 106 (13.7) | 0.69 (0.48-0.99) | −0.37 | .044 |
| Ref/Rel | 237 (29.7) | 1.23 (0.97-1.55) | 0.20 | .086 |
Multivariate analysis was conducted for 793 patients whose outcome data were available.
95% CI, 95% confidence interval; Coeff., coefficient; CR, complete remission; Dx, diagnosis; HR, hazard ratio; PS, performance status; Ref/Rel, refractory or relapse.