Strategies to target factor XII or factor XI
| Strategy . | Mechanism of action . |
|---|---|
| Antisense oligonucleotides | Reduce hepatic synthesis of factor XII or factor XI |
| Aptamers | Bind factor XII or factor XI and block activity |
| Antibodies | Bind factor XII or factor XI and block activation or activity |
| Small molecules | Bind reversibly to active site of factor XIIa or factor XIa and block activity |
| Polyanion antagonists | Neutralize polyphosphates or nucleic acids via ionic interactions, thereby attenuating contact pathway activation |
| Strategy . | Mechanism of action . |
|---|---|
| Antisense oligonucleotides | Reduce hepatic synthesis of factor XII or factor XI |
| Aptamers | Bind factor XII or factor XI and block activity |
| Antibodies | Bind factor XII or factor XI and block activation or activity |
| Small molecules | Bind reversibly to active site of factor XIIa or factor XIa and block activity |
| Polyanion antagonists | Neutralize polyphosphates or nucleic acids via ionic interactions, thereby attenuating contact pathway activation |